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Sat2 spermidine/spermine N1-acetyl transferase 2 [ Mus musculus (house mouse) ]

Gene ID: 69215, updated on 5-Mar-2024

Summary

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Official Symbol
Sat2provided by MGI
Official Full Name
spermidine/spermine N1-acetyl transferase 2provided by MGI
Primary source
MGI:MGI:1916465
See related
Ensembl:ENSMUSG00000069835 AllianceGenome:MGI:1916465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SSAT2; SSAT-2; 2610016A03Rik
Summary
Predicted to enable diamine N-acetyltransferase activity; identical protein binding activity; and spermidine binding activity. Predicted to be involved in polyamine metabolic process. Predicted to act upstream of or within spermidine metabolic process and spermine metabolic process. Predicted to be located in cytoplasm. Orthologous to human SAT2 (spermidine/spermine N1-acetyltransferase family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 6.0), bladder adult (RPKM 5.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Sat2 in Genome Data Viewer
Location:
11 B3; 11 42.86 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69512824..69514857)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69621996..69624032)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29854 Neighboring gene ATPase, Na+/K+ transporting, beta 2 polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E10681 Neighboring gene sex hormone binding globulin Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene FMR1 autosomal homolog 2 Neighboring gene microRNA 467f

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SAT2 regulates Sertoli cell-germline interactions via STIM1-mediated ROS/WNT/β-catenin signaling pathway. Chen X, et al. Cell Biol Int, 2022 Oct. PMID 35819096
  2. Spermidine/spermine-N(1)-acetyltransferase ablation impacts tauopathy-induced polyamine stress response. Sandusky-Beltran LA, et al. Alzheimers Res Ther, 2019 Jun 29. PMID 31253191, Free PMC Article
  3. Increased Sat2 expression is associated with busulfan-induced testicular Sertoli cell injury. Xian Y, et al. Toxicol In Vitro, 2017 Sep. PMID 28578006
  4. Spermidine/spermine-N1-acetyltransferase ablation protects against liver and kidney ischemia-reperfusion injury in mice. Zahedi K, et al. Am J Physiol Gastrointest Liver Physiol, 2009 Apr. PMID 19164485, Free PMC Article
  5. Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse. Berger FG, et al. Biochem Soc Trans, 2007 Apr. PMID 17371273

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SAT2 regulates Sertoli cell-germline interactions via STIM1-mediated ROS/WNT/beta-catenin signaling pathway.
    Title: SAT2 regulates Sertoli cell-germline interactions via STIM1-mediated ROS/WNT/β-catenin signaling pathway.
  2. Spermidine/spermine-N(1)-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.
    Title: Spermidine/spermine-N(1)-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.
  3. In testis tissue subjected to busulfan, increased expression of Sat2 can cause cellular injury and subsequent organ damage, which could lead to male infertility. Therefore, Sat2 may be a novel molecular target for treating busulfan-induced testicular toxicity.
    Title: Increased Sat2 expression is associated with busulfan-induced testicular Sertoli cell injury.
  4. These studies indicate that SAT2 deficient animals are protected against ischemia-reperfusion injuries (IRI) and suggest that SAT2 is an important mediator of the tissue damage in IRI.
    Title: Spermidine/spermine-N1-acetyltransferase ablation protects against liver and kidney ischemia-reperfusion injury in mice.
  5. Sat2 acts as a tumor promoter in the adenomaatous polyposis coli mouse (Min/+) model.
    Title: Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC74376

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables diamine N-acetyltransferase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nor-spermidine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in putrescine acetylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermidine metabolic process ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in spermine acetylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermine metabolic process ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thialysine N-epsilon-acetyltransferase
Names
diamine acetyltransferase 2
polyamine N-acetyltransferase 2
spermidine/spermine N(1)-acetyltransferase 2
NP_001343397.1
NP_001343398.1
NP_081267.1
XP_006534173.1
XP_006534174.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356468.1 → NP_001343397.1  thialysine N-epsilon-acetyltransferase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AI413743, AK011406, AV097768
    Consensus CDS
    CCDS36194.1
    UniProtKB/Swiss-Prot
    Q5F299, Q6P8J2
    UniProtKB/TrEMBL
    A0A158SIT0
    Related
    ENSMUSP00000090647.2, ENSMUST00000092969.2
    Conserved Domains (1) summary
    pfam00583
    Location:71 → 144
    Acetyltransf_1; Acetyltransferase (GNAT) family

  2. NM_001356469.1 → NP_001343398.1  thialysine N-epsilon-acetyltransferase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a novel 3' terminal exon, resulting in novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK161230, BE995938
    UniProtKB/TrEMBL
    Q3TTS0
    Related
    ENSMUST00000151255.2
    Conserved Domains (1) summary
    cl26092
    Location:6 → 106
    Acetyltransf_10; Acetyltransferase (GNAT) domain

  3. NM_026991.3 → NP_081267.1  thialysine N-epsilon-acetyltransferase isoform 1

    See identical proteins and their annotated locations for NP_081267.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AI413743, AK011406, AV097768, DV064807
    Consensus CDS
    CCDS36194.1
    UniProtKB/Swiss-Prot
    Q5F299, Q6P8J2
    UniProtKB/TrEMBL
    A0A158SIT0
    Related
    ENSMUSP00000104296.3, ENSMUST00000108656.9
    Conserved Domains (1) summary
    pfam00583
    Location:71 → 144
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69512824..69514857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534111.4 → XP_006534174.1  thialysine N-epsilon-acetyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006534174.1

    Conserved Domains (2) summary
    COG0456
    Location:6 → 167
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:94 → 167
    Acetyltransf_1; Acetyltransferase (GNAT) family

  2. XM_006534110.3 → XP_006534173.1  thialysine N-epsilon-acetyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006534173.1

    Conserved Domains (2) summary
    COG0456
    Location:6 → 167
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:94 → 167
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P8J2.1 GenPept UniProtKB/Swiss-Prot:Q6P8J2

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