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Ddah1 dimethylarginine dimethylaminohydrolase 1 [ Mus musculus (house mouse) ]

Gene ID: 69219, updated on 23-Jun-2021

Summary

Official Symbol
Ddah1provided by MGI
Official Full Name
dimethylarginine dimethylaminohydrolase 1provided by MGI
Primary source
MGI:MGI:1916469
See related
Ensembl:ENSMUSG00000028194
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI987801; AW050362; 2410006N07Rik; 2510015N06Rik
Expression
Broad expression in kidney adult (RPKM 50.5), liver adult (RPKM 34.0) and 18 other tissues See more
Orthologs
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Genomic context

See Ddah1 in Genome Data Viewer
Location:
3; 3 H2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (145464447..145600032)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (145758692..145894277)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (145421656..145557241)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17501 Neighboring gene cellular communication network factor 1 Neighboring gene ribosomal protein L36A, pseudogene 2 Neighboring gene predicted gene, 35187 Neighboring gene RIKEN cDNA 2410004B18 gene Neighboring gene B cell leukemia/lymphoma 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amino acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables dimethylargininase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dimethylargininase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables dimethylargininase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in arginine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in arginine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in arginine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in citrulline metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in citrulline metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein nitrosylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Names
DDAH-1
DDAHI
dimethylargininase-1
NP_081269.1
XP_011238523.1
XP_017175201.1
XP_030108663.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026993.3NP_081269.1  N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

    See identical proteins and their annotated locations for NP_081269.1

    Status: VALIDATED

    Source sequence(s)
    AK010970, AK148907, AK149185
    Consensus CDS
    CCDS17896.1
    UniProtKB/Swiss-Prot
    Q9CWS0
    UniProtKB/TrEMBL
    Q3UF01
    Related
    ENSMUSP00000029845.9, ENSMUST00000029845.15
    Conserved Domains (1) summary
    cl19186
    Location:11276
    Amidinotransf; Amidinotransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    145464447..145600032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240221.4XP_011238523.1  N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform X2

    See identical proteins and their annotated locations for XP_011238523.1

    UniProtKB/TrEMBL
    D3YU15
    Conserved Domains (1) summary
    cl19186
    Location:3173
    Amidinotransf; Amidinotransferase
  2. XM_030252803.1XP_030108663.1  N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform X2

    Related
    ENSMUSP00000112747.2, ENSMUST00000120310.2
    Conserved Domains (1) summary
    cl19186
    Location:3173
    Amidinotransf; Amidinotransferase
  3. XM_017319712.2XP_017175201.1  N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform X1

    Conserved Domains (1) summary
    cl19186
    Location:23193
    Amidinotransf; Amidinotransferase
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