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Cbp carotenoid-binding protein [ Bombyx mori (domestic silkworm) ]

Gene ID: 692547, updated on 10-May-2024

Summary

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Gene symbol
Cbp
Gene description
carotenoid-binding protein
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bombyx mori
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea; Bombycidae; Bombycinae; Bombyx
Also known as
Start1
Orthologs
fruit fly all
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Genomic context

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Location:
chromosome: 2
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_01 current ASM3026992v2 (GCF_030269925.1) 2 NC_085108.1 (6375583..6416504)
103 previous assembly Bmori_2016v1.0 (GCF_014905235.1) 2 NC_051359.1 (6366141..6407060)

Chromosome 2 - NC_085108.1Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase UGT33R2 Neighboring gene uncharacterized LOC105842582 Neighboring gene uncharacterized LOC119629498 Neighboring gene uncharacterized LOC134200522 Neighboring gene histone H1 Neighboring gene uncharacterized LOC101736380

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of a silkworm F₁ hybrid with yellow cocoon generated by crossing two white-cocoon strains: further evidences for the roles of Cameo2 and CBP in formation of yellow cocoon. Chai C, et al. Gene, 2014 Jan 15. PMID 24157262
  2. BmStart1, a novel carotenoid-binding protein isoform from Bombyx mori, is orthologous to MLN64, a mammalian cholesterol transporter. Sakudoh T, et al. Biochem Biophys Res Commun, 2005 Nov 4. PMID 16169523
  3. 20-Hydroxyecdysone receptor-activated Bombyx mori CCAAT/enhancer-binding protein gamma regulates the expression of BmCBP and subsequent histone H3 lysine 27 acetylation in Bo. mori. Lyu H, et al. Insect Mol Biol, 2020 Apr. PMID 31840914
  4. Combined effect of Cameo2 and CBP on the cellular uptake of lutein in the silkworm, Bombyx mori. Wang W, et al. PLoS One, 2014. PMID 24475153, Free PMC Article
  5. Carotenoid silk coloration is controlled by a carotenoid-binding protein, a product of the Yellow blood gene. Sakudoh T, et al. Proc Natl Acad Sci U S A, 2007 May 22. PMID 17496138, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 20-Hydroxyecdysone receptor-activated Bombyx mori CCAAT/enhancer-binding protein gamma regulates the expression of BmCBP and subsequent histone H3 lysine 27 acetylation in Bo. mori.
    Title: 20-Hydroxyecdysone receptor-activated Bombyx mori CCAAT/enhancer-binding protein gamma regulates the expression of BmCBP and subsequent histone H3 lysine 27 acetylation in Bo. mori.
  2. Cameo2 and CBP are necessarily expressed in midguts and silk glands for lutein uptake in Bombyx mori.
    Title: Combined effect of Cameo2 and CBP on the cellular uptake of lutein in the silkworm, Bombyx mori.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in vesicle tethering to endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum-endosome membrane contact site IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
carotenoid-binding protein
Names
putative cholesterol transporter BmStart1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001043533.2 → NP_001036998.2  carotenoid-binding protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB211534, BABH01017793
    UniProtKB/TrEMBL
    A0A8R1XEG7, Q3V5Y6
    Conserved Domains (2) summary
    cd08868
    Location:246 → 470
    START_STARD1_3_like; Cholesterol-binding START domain of mammalian STARD1, -3 and related proteins
    pfam10457
    Location:49 → 227
    MENTAL; Cholesterol-capturing domain

  2. NM_001110362.2 → NP_001103832.2  carotenoid-binding protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK377911
    UniProtKB/TrEMBL
    A0A8R2QWT8, X2F9Z2
    Conserved Domains (1) summary
    cl14643
    Location:1 → 212
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

RefSeqs of Annotated Genomes: GCF_030269925.1-RS_2024_01

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM3026992v2 Primary Assembly

Genomic

  1. NC_085108.1 Reference ASM3026992v2 Primary Assembly

    Range
    6375583..6416504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038014834.2 → XP_037870762.1  carotenoid-binding protein isoform X1

    UniProtKB/TrEMBL
    A0A8R1XEG7, Q3V5Y6
    Conserved Domains (2) summary
    cd08868
    Location:246 → 470
    START_STARD1_3_like; Cholesterol-binding START domain of mammalian STARD1, -3 and related proteins
    pfam10457
    Location:49 → 227
    MENTAL; Cholesterol-capturing domain

  2. XM_062671785.1 → XP_062527769.1  carotenoid-binding protein isoform X1

    UniProtKB/TrEMBL
    A0A8R1XEG7

  3. XM_038014875.2 → XP_037870803.1  carotenoid-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A8R2QWT8, X2F9Z2
    Conserved Domains (1) summary
    cl14643
    Location:1 → 212
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  4. XM_038014854.2 → XP_037870782.1  carotenoid-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A8R2QWT8, X2F9Z2
    Conserved Domains (1) summary
    cl14643
    Location:1 → 212
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  5. XM_038014841.2 → XP_037870769.1  carotenoid-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A8R2QWT8, X2F9Z2
    Conserved Domains (1) summary
    cl14643
    Location:1 → 212
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  6. XM_038014844.2 → XP_037870772.1  carotenoid-binding protein isoform X4

    UniProtKB/TrEMBL
    A0A8R2QYW6, X2F9Z2
    Conserved Domains (1) summary
    cd08868
    Location:2 → 224
    START_STARD1_3_like; Cholesterol-binding START domain of mammalian STARD1, -3 and related proteins

  7. XM_038014843.2 → XP_037870771.1  carotenoid-binding protein isoform X3

    UniProtKB/TrEMBL
    A0A8R2M050, X2F9Z2
    Conserved Domains (1) summary
    cd08868
    Location:6 → 228
    START_STARD1_3_like; Cholesterol-binding START domain of mammalian STARD1, -3 and related proteins

  8. XM_038014876.2 → XP_037870804.1  carotenoid-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A8R2QWT8, X2F9Z2
    Conserved Domains (1) summary
    cl14643
    Location:1 → 212
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  9. XM_038014865.2 → XP_037870793.1  carotenoid-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A8R2QWT8, X2F9Z2
    Conserved Domains (1) summary
    cl14643
    Location:1 → 212
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  10. XM_062671796.1 → XP_062527780.1  carotenoid-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A8R2QWT8

  11. XM_038014872.2 → XP_037870800.1  carotenoid-binding protein isoform X2

    UniProtKB/TrEMBL
    A0A8R2QWT8, X2F9Z2
    Conserved Domains (1) summary
    cl14643
    Location:1 → 212
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
Nucleotide Protein
Heading Accession and Version

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