CAPN1 calpain 1 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: CAPN1provided by CGNC
Official Full Name: calpain 1provided by CGNC
Primary source: CGNC:49714
See related: Ensembl:ENSGALG00010001351
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: calpain
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 39

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	39 Unlocalized Scaffold	NW_024095974.1 (75004..90181)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	39 Unlocalized Scaffold	NW_024096226.1 (35478..47053)

NW_024095974.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A significant association between the MC4R genotype and body weight at 2, 4, and 10 wk of age was detected. Chickens possessing the BB genotype of CAPN1 showed significantly heavier body weight at 6 wk of age and guanine content at 4 wk of age, compared with those of the other genotypes. In addition, high expression levels of the CAPN1 and ADSL genes were detected in the breast muscle at 2 wk of age.
Title: Effects of the MC4R, CAPN1, and ADSL genes on body weight and purine content in slow-growing chickens.
mu-calpain plays a major role in meat quality changes while mu/m-calpain could also be involved but played a limited role in the proteolysis and meat quality changes during 12 h to 7 days postmortem storage of chicken breast muscle.
Title: Involvement of μ/m-calpain in the proteolysis and meat quality changes during postmortem storage of chicken breast muscle.
We found that, for CAPN1, genetic effects between SNPs (G3535A, C7198A) and meat tenderness were similar in different generations, while SNP3 (G7324A) was a novel polymorphism and had significant association with carcass and tenderness traits (P < 0.05) in this study.
Title: Experimental Verification of CAPN1 and CAST Gene Polymorphisms in Different Generations of Da-Heng Broilers.
CAPN1 gene polymorphisms affect chicken meat tenderness
Title: Analysis of the genetic effects of CAPN1 gene polymorphisms on chicken meat tenderness.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium-dependent cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: calpain-1 catalytic subunit

Names: calcium-activated neutral proteinase; calpain 1, (mu/I) large subunit; calpain-1 large subunit; mu-calpain large subunit

NP_001038137.2

EC 3.4.22.52

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.