U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BF1 major histocompatibility complex B, class I heavy chain BF1 [ Gallus gallus (chicken) ]

Gene ID: 693260, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Symbol
BF1provided by CGNC
Full Name
major histocompatibility complex B, class I heavy chain BF1provided by CGNC
Primary source
CGNC:54365
See related
Ensembl:ENSGALG00010003110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
BF; B-F; HFE; B-F1; B-FI; BFa2; B-FIV; BFw-03; BFw-05; BFz-01; B-F-S04; B-F-S05; B-F-S06; B-F-S07
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 16
Exon count:
8
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 16 NC_052547.1 (2213458..2216245)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 16 NC_052588.1 (1114587..1117375)

Chromosome 16 - NC_052547.1Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex B, class II alpha chain DMA Neighboring gene major histocompatibility complex B, class II beta chain DMB1 Neighboring gene major histocompatibility complex B, class II beta chain DMB2 Neighboring gene transporter 1, ATP binding cassette subfamily B member, MHCB region Neighboring gene transporter 2, ATP binding cassette subfamily B member, MHCB region

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The chicken BF1 (classical MHC class I) gene shows evidence of selection for diversity in expression and in promoter and signal peptide regions. O'Neill AM, et al. Immunogenetics, 2009 Apr. PMID 19212763
  2. B-F DNA sequence variability in Brazilian (blue-egg Caipira) chickens. Lima-Rosa CA, et al. Anim Genet, 2004 Aug. PMID 15265066
  3. Molecular analysis reveals MHC class I intra-locus recombination in the chicken. Hunt HD, et al. Immunogenetics, 1994. PMID 7927541
  4. Two class I genes of the chicken MHC have different functions: BF1 is recognized by NK cells while BF2 is recognized by CTLs. Kim T, et al. Immunogenetics, 2018 Sep. PMID 29947944
  5. Different evolutionary histories of the two classical class I genes BF1 and BF2 illustrate drift and selection within the stable MHC haplotypes of chickens. Shaw I, et al. J Immunol, 2007 May 1. PMID 17442958

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes.
    Title: The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes.
  2. BF1 negatively regulates the natural killer cell killing activity.
    Title: Two class I genes of the chicken MHC have different functions: BF1 is recognized by NK cells while BF2 is recognized by CTLs.
  3. Results showed that all BF1 alleles exhibit conservation of most of the identified promoter elements, but divergence from the Enhancer A sequence identified in the more highly expressed BF2 locus.
    Title: The chicken BF1 (classical MHC class I) gene shows evidence of selection for diversity in expression and in promoter and signal peptide regions.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
MHC BF1 class I
Names
B-F minor
MHC class I alpha chain 1
MHC class I antigen B-F minor heavy chain
MHC class I antigen alpha chain
MHC class I antigen heavy chain
MHC class I glycoprotein
MHC class1 antigen
major histocompatibility complex, class I, G

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044683.3 → NP_001038148.2  MHC BF1 class I precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000283
    UniProtKB/TrEMBL
    A0ZXL3, A0ZXL5, B5BST4, F1NS77
    Related
    ENSGALP00010004373.1, ENSGALT00010007289.1
    Conserved Domains (3) summary
    cd07698
    Location:206 → 297
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    smart00410
    Location:221 → 284
    IG_like; Immunoglobulin like
    pfam00129
    Location:27 → 202
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052547.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    2213458..2216245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040648641.2 → XP_040504575.1  MHC BF1 class I isoform X1

    UniProtKB/TrEMBL
    A0A8V0XCI4
    Conserved Domains (2) summary
    pfam00129
    Location:27 → 202
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cd21029
    Location:206 → 296
    IgC1_CD1; Immunoglobulin domain of Cluster of Differentiation (CD) 1; member of the C1-set of Ig superfamily (IgSF) domains

  2. XM_015294996.4 → XP_015150482.1  MHC BF1 class I isoform X2

    UniProtKB/TrEMBL
    A0A8V0XCI4
    Related
    ENSGALP00010004372.1, ENSGALT00010007287.1
    Conserved Domains (3) summary
    cd07698
    Location:206 → 297
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    smart00410
    Location:221 → 284
    IG_like; Immunoglobulin like
    pfam00129
    Location:27 → 202
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052588.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    1114587..1117375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046928563.1 → XP_046784519.1  MHC BF1 class I isoform X1

  2. XM_046928564.1 → XP_046784520.1  MHC BF1 class I isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
T28149 GenPept UniProt:T28149

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.