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Wdr5b WD repeat domain 5B [ Mus musculus (house mouse) ]

Gene ID: 69544, updated on 5-Mar-2024

Summary

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Official Symbol
Wdr5bprovided by MGI
Official Full Name
WD repeat domain 5Bprovided by MGI
Primary source
MGI:MGI:1916794
See related
Ensembl:ENSMUSG00000034379 AllianceGenome:MGI:1916794
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310009C03Rik
Summary
Predicted to enable histone binding activity. Predicted to be involved in histone H3-K4 methylation. Predicted to be part of Set1C/COMPASS complex. Orthologous to human WDR5B (WD repeat domain 5B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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See Wdr5b in Genome Data Viewer
Location:
16 B3; 16 25.43 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (35861560..35863344)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36041190..36042974)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) polymerase family, member 9 Neighboring gene STARR-seq mESC enhancer starr_40752 Neighboring gene predicted gene 15564 Neighboring gene karyopherin subunit alpha 1 Neighboring gene STARR-positive B cell enhancer ABC_E5540 Neighboring gene family with sequence similarity 162, member A Neighboring gene STARR-seq mESC enhancer starr_40755 Neighboring gene mitochondrial matrix import factor 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Higa LA, et al. Nat Cell Biol, 2006 Nov. PMID 17041588
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027113.2 → NP_081389.1  WD repeat-containing protein 5B

    See identical proteins and their annotated locations for NP_081389.1

    Status: PROVISIONAL

    Source sequence(s)
    BC064045
    Consensus CDS
    CCDS28145.1
    UniProtKB/Swiss-Prot
    Q9D7H2
    Related
    ENSMUSP00000040852.9, ENSMUST00000042203.10
    Conserved Domains (3) summary
    COG2319
    Location:34 → 325
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:31 → 325
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:42 → 79
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    35861560..35863344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7H2.1 GenPept UniProtKB/Swiss-Prot:Q9D7H2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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