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Klhdc2 kelch domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 69554, updated on 16-Oct-2021

Summary

Official Symbol
Klhdc2provided by MGI
Official Full Name
kelch domain containing 2provided by MGI
Primary source
MGI:MGI:1916804
See related
Ensembl:ENSMUSG00000020978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LCP; HCLP-1; D12Ertd522e; 2310022K15Rik
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 57.4), CNS E18 (RPKM 56.1) and 28 other tissues See more
Orthologs
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Genomic context

See Klhdc2 in Genome Data Viewer
Location:
12 C2; 12 28.77 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69343455..69357461)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69296681..69310687)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (70397668..70411674)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330151L19 gene Neighboring gene dynein, axonemal assembly factor 2 Neighboring gene polymerase (DNA directed), epsilon 2 (p59 subunit) Neighboring gene kelch domain containing 1 Neighboring gene nuclear export mediator factor Neighboring gene 7S RNA 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kelch domain-containing protein 2
Names
endothelial differentiation inhibitory protein TNG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027117.3NP_081393.2  kelch domain-containing protein 2

    See identical proteins and their annotated locations for NP_081393.2

    Status: VALIDATED

    Source sequence(s)
    AC099934, AK009481
    Consensus CDS
    CCDS25950.1
    UniProtKB/Swiss-Prot
    Q4G5Y1
    Related
    ENSMUSP00000021362.5, ENSMUST00000021362.5
    Conserved Domains (3) summary
    PLN02193
    Location:29296
    PLN02193; nitrile-specifier protein
    sd00038
    Location:218265
    Kelch; KELCH repeat [structural motif]
    pfam13415
    Location:279326
    Kelch_3; Galactose oxidase, central domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    69343455..69357461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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