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Fastkd3 FAST kinase domains 3 [ Mus musculus (house mouse) ]

Gene ID: 69577, updated on 23-Jun-2021

Summary

Official Symbol
Fastkd3provided by MGI
Official Full Name
FAST kinase domains 3provided by MGI
Primary source
MGI:MGI:1916827
See related
Ensembl:ENSMUSG00000021532
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AW048587; 2310010B21Rik
Expression
Ubiquitous expression in limb E14.5 (RPKM 5.9), CNS E11.5 (RPKM 5.3) and 28 other tissues See more
Orthologs
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Genomic context

See Fastkd3 in Genome Data Viewer
Location:
13; 13 B3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (68730281..68740457)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (68582167..68592338)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (68721125..68731156)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46386 Neighboring gene VISTA enhancer mm1330 Neighboring gene RIKEN cDNA 1700001L19 gene Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Neighboring gene predicted gene, 34903 Neighboring gene adenylate cyclase 2 Neighboring gene farnesyl diphosphate synthetase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial cytochrome c oxidase assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrial mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mitochondrial mRNA stability ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
FAST kinase domain-containing protein 3, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330423.1NP_001317352.1  FAST kinase domain-containing protein 3, mitochondrial

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK033189, CA560457, CJ265660, CT033781
    Consensus CDS
    CCDS36719.1
    UniProtKB/Swiss-Prot
    Q8BSN9
  2. NM_027123.5NP_081399.3  FAST kinase domain-containing protein 3, mitochondrial

    See identical proteins and their annotated locations for NP_081399.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK033189, CJ265660, CT033781
    Consensus CDS
    CCDS36719.1
    UniProtKB/Swiss-Prot
    Q8BSN9
    Related
    ENSMUSP00000061737.9, ENSMUST00000051784.10
    Conserved Domains (3) summary
    smart00952
    Location:594651
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:410478
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:494580
    FAST_2; FAST kinase-like protein, subdomain 2

RNA

  1. NR_138477.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK032530, AK033189, CJ265660, CT033781
    Related
    ENSMUST00000223319.2
  2. NR_138478.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon and uses alternate splice sites in the second exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AK033189, AW988524, CJ265660, CT033781
    Related
    ENSMUST00000222068.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    68730281..68740457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315595.2XP_017171084.1  FAST kinase domain-containing protein 3, mitochondrial isoform X3

    Conserved Domains (2) summary
    smart00952
    Location:381438
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam08368
    Location:281367
    FAST_2; FAST kinase-like protein, subdomain 2
  2. XM_006517364.4XP_006517427.1  FAST kinase domain-containing protein 3, mitochondrial isoform X1

    Conserved Domains (3) summary
    smart00952
    Location:631688
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:447515
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:531617
    FAST_2; FAST kinase-like protein, subdomain 2
  3. XM_006517366.4XP_006517429.1  FAST kinase domain-containing protein 3, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006517429.1

    Conserved Domains (3) summary
    smart00952
    Location:397454
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:213281
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:297383
    FAST_2; FAST kinase-like protein, subdomain 2
  4. XM_006517367.1XP_006517430.1  FAST kinase domain-containing protein 3, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006517430.1

    Conserved Domains (3) summary
    smart00952
    Location:397454
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:213281
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:297383
    FAST_2; FAST kinase-like protein, subdomain 2

RNA

  1. XR_004938066.1 RNA Sequence

  2. XR_382449.4 RNA Sequence

  3. XR_003950475.1 RNA Sequence

  4. XR_004938067.1 RNA Sequence

  5. XR_003950476.1 RNA Sequence

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