Format

Send to:

Choose Destination

Exosc8 exosome component 8 [ Mus musculus (house mouse) ]

Gene ID: 69639, updated on 8-Aug-2021

Summary

Official Symbol
Exosc8provided by MGI
Official Full Name
exosome component 8provided by MGI
Primary source
MGI:MGI:1916889
See related
Ensembl:ENSMUSG00000027752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CIP3; mKIAA4013; 2310032N20Rik
Expression
Broad expression in CNS E11.5 (RPKM 31.7), liver E14 (RPKM 25.7) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Exosc8 in Genome Data Viewer
Location:
3; 3 C
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (54636100..54642785, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (54728679..54735364, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (54532601..54539286, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40050 Neighboring gene REX1, RNA exonuclease 1 homolog pseudogene Neighboring gene SPT20 SAGA complex component Neighboring gene asparagine-linked glycosylation 5 (dolichyl-phosphate beta-glucosyltransferase) Neighboring gene SMAD family member 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4013

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in RNA catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in U1 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in U5 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in exonucleolytic catabolism of deadenylated mRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear polyadenylation-dependent mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear polyadenylation-dependent tRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
exosome complex component RRP43
Names
exosome complex exonuclease RRP43
ribosomal RNA-processing protein 43
NP_001157042.1
NP_081424.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163570.1NP_001157042.1  exosome complex component RRP43 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA003291, AK220227
    UniProtKB/TrEMBL
    Q571G2
    Conserved Domains (2) summary
    cd11369
    Location:6270
    RNase_PH_RRP43; RRP43 subunit of eukaryotic exosome
    PRK04282
    Location:12276
    PRK04282; exosome complex RNA-binding protein Rrp42; Provisional
  2. NM_027148.3NP_081424.3  exosome complex component RRP43 isoform 2

    See identical proteins and their annotated locations for NP_081424.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK220227
    Consensus CDS
    CCDS17352.1
    UniProtKB/Swiss-Prot
    Q9D753
    UniProtKB/TrEMBL
    Q546F8, Q571G2
    Related
    ENSMUSP00000029316.10, ENSMUST00000029316.16
    Conserved Domains (2) summary
    cd11369
    Location:6266
    RNase_PH_RRP43; RRP43 subunit of eukaryotic exosome
    PRK04282
    Location:12272
    PRK04282; exosome complex RNA-binding protein Rrp42; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    54636100..54642785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center