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Pxdn peroxidasin [ Mus musculus (house mouse) ]

Gene ID: 69675, updated on 21-Apr-2024

Summary

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Official Symbol
Pxdnprovided by MGI
Official Full Name
peroxidasinprovided by MGI
Primary source
MGI:MGI:1916925
See related
Ensembl:ENSMUSG00000020674 AllianceGenome:MGI:1916925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VPO1; mKIAA0230; E330004E07; 2310075M15Rik
Summary
Predicted to enable bromide peroxidase activity and heme binding activity. Predicted to be an extracellular matrix structural constituent. Involved in extracellular matrix organization. Located in collagen-containing extracellular matrix. Is expressed in several structures, including branchial arch; central nervous system; gut; heart; and sensory organ. Human ortholog(s) of this gene implicated in anterior segment dysgenesis 7. Orthologous to human PXDN (peroxidasin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 54.0), limb E14.5 (RPKM 52.0) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A2; 12 13.0 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (29986641..30067657)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (29936642..30017658)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene myelin transcription factor 1-like Neighboring gene predicted gene, 53715 Neighboring gene predicted gene, 46346 Neighboring gene predicted gene, 31939 Neighboring gene STARR-seq mESC enhancer starr_31838 Neighboring gene STARR-seq mESC enhancer starr_31839 Neighboring gene STARR-seq mESC enhancer starr_31840 Neighboring gene STARR-seq mESC enhancer starr_31841 Neighboring gene predicted gene 15691 Neighboring gene thyroid peroxidase Neighboring gene predicted gene, 40873

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix. Bathish B, et al. J Biol Chem, 2020 Sep 4. PMID 32675287, Free PMC Article
  2. Biallelic Deletion of Pxdn in Mice Leads to Anophthalmia and Severe Eye Malformation. Kim HK, et al. Int J Mol Sci, 2019 Dec 5. PMID 31817535, Free PMC Article
  3. Peroxidasin contributes to lung host defense by direct binding and killing of gram-negative bacteria. Shi R, et al. PLoS Pathog, 2018 May. PMID 29775486, Free PMC Article
  4. The sulfilimine cross-link of collagen IV contributes to kidney tubular basement membrane stiffness. Bhave G, et al. Am J Physiol Renal Physiol, 2017 Sep 1. PMID 28424209, Free PMC Article
  5. Peroxidasin Deficiency Re-programs Macrophages Toward Pro-fibrolysis Function and Promotes Collagen Resolution in Liver. Sojoodi M, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 35093588, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults.
    Title: Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults.
  2. Peroxidasin Deficiency Re-programs Macrophages Toward Pro-fibrolysis Function and Promotes Collagen Resolution in Liver.
    Title: Peroxidasin Deficiency Re-programs Macrophages Toward Pro-fibrolysis Function and Promotes Collagen Resolution in Liver.
  3. Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix.
    Title: Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix.
  4. these results suggest that PXDN activity is essential in eye development, and also indicate that a single allele of Pxdn gene is sufficient for eye-structure formation and normal visual function.
    Title: Biallelic Deletion of Pxdn in Mice Leads to Anophthalmia and Severe Eye Malformation.
  5. Peroxidasin contributes to renal fibrosis in the murine unilateral ureteral obstruction model.
    Title: Peroxidasin and eosinophil peroxidase, but not myeloperoxidase, contribute to renal fibrosis in the murine unilateral ureteral obstruction model.
  6. we conclude that VPO1 is a crucial regulator of cardiac fibrosis after MI by mediating HOCl/Smad2/3 and ERK1/2 signaling pathways, implying a promising therapeutic target in ischemic cardiomyopathy.
    Title: Vascular peroxidase 1 is a novel regulator of cardiac fibrosis after myocardial infarction.
  7. Vpo1 is upregulated in elastase-induced mouse abdominal aortic aneurysmal tissues compared with healthy control tissues.
    Title: VPO1 Modulates Vascular Smooth Muscle Cell Phenotypic Switch by Activating Extracellular Signal-regulated Kinase 1/2 (ERK 1/2) in Abdominal Aortic Aneurysms.
  8. Data suggest that VPO1 contributes to oxidation and retention of LDL in vessel walls, and formation foam cells, indicating VPO1 as a novel potential mediator of atherosclerosis.
    Title: VPO1 mediates oxidation of LDL and formation of foam cells.
  9. Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit (Col4a1, GPBP, Lamc1, peroxidasin) during uterine reprogramming.
    Title: Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming.
  10. Cdkn1b exert its effects via the inhibition of proliferation and is mediated by miR-24 and targeted by the transcription factors FOXO4 and AP4 in the peroxidasin (Pxdn) mutation-induced eye disorders, such as glaucoma.
    Title: An examination of the regulatory mechanism of Pxdn mutation-induced eye disorders using microarray analysis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent ISO
Inferred from Sequence Orthology
more info
  
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables laminin-1 binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on peroxide as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on peroxide as acceptor IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity, acting on peroxide as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in basement membrane assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in basement membrane assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of basement membrane assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in basement membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in collagen fibril organization ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular matrix organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
involved_in eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotrimerization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxidasin homolog
NP_852060.2
XP_006515268.1
XP_006515269.1
XP_036013501.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181395.2 → NP_852060.2  peroxidasin homolog precursor

    See identical proteins and their annotated locations for NP_852060.2

    Status: VALIDATED

    Source sequence(s)
    AK142872, BC112913, BP772471
    Consensus CDS
    CCDS25856.1
    UniProtKB/Swiss-Prot
    A4FU83, E9QNQ9, Q3UQ28
    UniProtKB/TrEMBL
    B2RX13
    Related
    ENSMUSP00000113703.2, ENSMUST00000122328.8
    Conserved Domains (12) summary
    cd05745
    Location:443 → 516
    Ig3_Peroxidasin; Third immunoglobulin (Ig)-like domain of peroxidasin
    cd05746
    Location:539 → 607
    Ig4_Peroxidasin; Fourth immunoglobulin (Ig)-like domain of peroxidasin
    cd09826
    Location:861 → 1300
    peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
    smart00214
    Location:1411 → 1466
    VWC; von Willebrand factor (vWF) type C domain
    pfam07679
    Location:430 → 516
    I-set; Immunoglobulin I-set domain
    sd00031
    Location:109 → 132
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:63 → 84
    LRR_RI; leucine-rich repeat [structural motif]
    pfam03098
    Location:738 → 1279
    An_peroxidase; Animal haem peroxidase
    pfam12799
    Location:107 → 148
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:108 → 167
    LRR_8; Leucine rich repeat
    cl11960
    Location:243 → 330
    Ig; Immunoglobulin domain
    cl15307
    Location:189 → 240
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    29986641..30067657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515205.4 → XP_006515268.1  peroxidasin homolog isoform X1

    UniProtKB/TrEMBL
    B2RX13
    Conserved Domains (9) summary
    cd05745
    Location:471 → 544
    Ig3_Peroxidasin; Third immunoglobulin (Ig)-like domain of peroxidasin
    cd05746
    Location:567 → 635
    Ig4_Peroxidasin; Fourth immunoglobulin (Ig)-like domain of peroxidasin
    cd09826
    Location:889 → 1328
    peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
    smart00214
    Location:1439 → 1494
    VWC; von Willebrand factor (vWF) type C domain
    sd00031
    Location:113 → 127
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:94 → 112
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:160 → 219
    LRR_8; Leucine rich repeat
    pfam07679
    Location:367 → 454
    I-set; Immunoglobulin I-set domain
    cl15307
    Location:217 → 268
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  2. XM_036157608.1 → XP_036013501.1  peroxidasin homolog isoform X2

    Conserved Domains (2) summary
    cd09826
    Location:170 → 609
    peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
    smart00214
    Location:720 → 775
    VWC; von Willebrand factor (vWF) type C domain

  3. XM_006515206.2 → XP_006515269.1  peroxidasin homolog isoform X2

    Conserved Domains (2) summary
    cd09826
    Location:170 → 609
    peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
    smart00214
    Location:720 → 775
    VWC; von Willebrand factor (vWF) type C domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177804.2: Suppressed sequence

    Description
    NM_177804.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UQ28.2 GenPept UniProtKB/Swiss-Prot:Q3UQ28

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