Nup37 nucleoporin 37 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nup37provided by MGI
Official Full Name: nucleoporin 37provided by MGI
Primary source: MGI:MGI:1919964
See related: Ensembl:ENSMUSG00000035351 AllianceGenome:MGI:1919964
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410003L22Rik; 2810039M17Rik
Summary: Predicted to act upstream of or within several processes, including chromosome segregation; mRNA transport; and protein transport. Predicted to be located in nucleoplasm. Predicted to be part of nuclear pore outer ring. Predicted to colocalize with kinetochore. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NUP37 (nucleoporin 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 13.9), placenta adult (RPKM 12.5) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 43.7 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (87982838..88014257)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (88146976..88178395)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nucleoporin37 may play a role in early embryo development in human and mice.
Title: Nucleoporin37 may play a role in early embryo development in human and mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235843

NoName (e-PCR)
- UniSTS:235844

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nucleocytoplasmic transport	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
colocalizes_with kinetochore	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	NAS Non-traceable Author Statement more info	PubMed
part_of nuclear pore outer ring	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore outer ring	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleoporin Nup37

Names: nup107-160 subcomplex subunit Nup37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027191.2 → NP_081467.2 nucleoporin Nup37

See identical proteins and their annotated locations for NP_081467.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK040463, BE951864

Consensus CDS

CCDS24107.1

UniProtKB/Swiss-Prot

Q9CWU9, Q9CZ80

Related

ENSMUSP00000059880.8, ENSMUST00000052355.15

Conserved Domains (3) summary

COG2319
Location:32 → 322

WD40; WD40 repeat [General function prediction only]

sd00039
Location:22 → 70

7WD40; WD40 repeat [structural motif]

cl02567
Location:64 → 260

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_028334.4 → NP_082610.1 nucleoporin Nup37

See identical proteins and their annotated locations for NP_082610.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK012890, AK165537, BE951864, CJ072834

Consensus CDS

CCDS24107.1

UniProtKB/Swiss-Prot

Q9CWU9, Q9CZ80

Related

ENSMUSP00000129728.2, ENSMUST00000169309.3

Conserved Domains (3) summary

COG2319
Location:32 → 322

WD40; WD40 repeat [General function prediction only]

sd00039
Location:22 → 70

7WD40; WD40 repeat [structural motif]

cl02567
Location:64 → 260

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

87982838..88014257

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514057.3 → XP_006514120.1 nucleoporin Nup37 isoform X1

Conserved Domains (2) summary

sd00039
Location:22 → 70

7WD40; WD40 repeat [structural motif]

cl29593
Location:64 → 237

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...