Aoc1l2 amine oxidase copper containing 1-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aoc1l2provided by MGI
Official Full Name: amine oxidase copper containing 1-like 2provided by MGI
Primary source: MGI:MGI:1917011
See related: Ensembl:ENSMUSG00000029813 AllianceGenome:MGI:1917011
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Doxl1; 1600015I10Rik
Summary: Predicted to enable several functions, including heparin binding activity; metal ion binding activity; and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Predicted to be involved in several processes, including cellular response to azide; cellular response to copper ion starvation; and cellular response to histamine. Predicted to be located in extracellular exosome. Predicted to be active in plasma membrane. Orthologous to human AOC1 (amine oxidase copper containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward placenta adult (RPKM 22.7) See more
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Genomic context

Location:: 6 B2.3; 6 23.79 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (48906830..48910621)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (48929896..48933687)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

AI429442 (e-PCR)
- UniSTS:159503

UniSTS:234646 (e-PCR)
- UniSTS:234646

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables diamine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diamine oxidase activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables histamine oxidase activity	ISO Inferred from Sequence Orthology more info
enables primary amine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables putrescine oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in putrescine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to antibiotic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: diamine oxidase-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081273.2 → NP_001074742.2 diamine oxidase-like protein 1 precursor

Status: VALIDATED

Source sequence(s)

AI426084, BC085280, BY033750, CA539018, CF916607

Consensus CDS

CCDS39484.2

UniProtKB/TrEMBL

E9Q745, Q6IMK8

Related

ENSMUSP00000031837.8, ENSMUST00000031837.8

Conserved Domains (4) summary

PLN02566
Location:60 → 707

PLN02566; amine oxidase (copper-containing)

pfam01179
Location:308 → 707

Cu_amine_oxid; Copper amine oxidase, enzyme domain

pfam02727
Location:51 → 136

Cu_amine_oxidN2; Copper amine oxidase, N2 domain

pfam02728
Location:152 → 252

Cu_amine_oxidN3; Copper amine oxidase, N3 domain