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Bdh2 3-hydroxybutyrate dehydrogenase, type 2 [ Mus musculus (house mouse) ]

Gene ID: 69772, updated on 22-Aug-2021

Summary

Official Symbol
Bdh2provided by MGI
Official Full Name
3-hydroxybutyrate dehydrogenase, type 2provided by MGI
Primary source
MGI:MGI:1917022
See related
Ensembl:ENSMUSG00000028167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dhr; Dhrs6; 1810026B04Rik
Expression
Biased expression in kidney adult (RPKM 79.3), liver adult (RPKM 4.6) and 1 other tissue See more
Orthologs
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Genomic context

See Bdh2 in Genome Data Viewer
Location:
3; 3 G3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (134986982..135010187)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135281221..135304426)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (134944185..134967390)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene centromere protein E Neighboring gene predicted gene, 46826 Neighboring gene solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 Neighboring gene solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in siderophore biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in siderophore biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
3-hydroxybutyrate dehydrogenase type 2
Names
R-beta-hydroxybutyrate dehydrogenase
dehydrogenase/reductase (SDR family) member 6
NP_001165526.1
NP_081484.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172055.1NP_001165526.1  3-hydroxybutyrate dehydrogenase type 2 isoform 1

    See identical proteins and their annotated locations for NP_001165526.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC104874
    Consensus CDS
    CCDS51073.1
    UniProtKB/TrEMBL
    G3UWD3
    Related
    ENSMUSP00000112683.3, ENSMUST00000120397.8
    Conserved Domains (2) summary
    cd05368
    Location:15255
    DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
    PRK06138
    Location:12254
    PRK06138; short chain dehydrogenase; Provisional
  2. NM_027208.2NP_081484.1  3-hydroxybutyrate dehydrogenase type 2 isoform 2

    See identical proteins and their annotated locations for NP_081484.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC104874
    Consensus CDS
    CCDS17853.1
    UniProtKB/Swiss-Prot
    Q8JZV9
    Related
    ENSMUSP00000029817.8, ENSMUST00000029817.11
    Conserved Domains (2) summary
    cd05368
    Location:5245
    DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
    PRK06138
    Location:2244
    PRK06138; short chain dehydrogenase; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    134986982..135010187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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