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A1cf APOBEC1 complementation factor [ Mus musculus (house mouse) ]

Gene ID: 69865, updated on 16-Apr-2024

Summary

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Official Symbol
A1cfprovided by MGI
Official Full Name
APOBEC1 complementation factorprovided by MGI
Primary source
MGI:MGI:1917115
See related
Ensembl:ENSMUSG00000052595 AllianceGenome:MGI:1917115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ASP; Acf; MCM; mer; ACF64; ACF65; MerCreMer; 1810073H04Rik; 9130016M20Rik; alpha-MHC-MerCreMer; alphaMHC-Cre-Mer-Cre; Tg(Myh6-cre/Esr1*)1Jmk
Summary
Predicted to enable mRNA binding activity and single-stranded RNA binding activity. Acts upstream of or within RNA modification; embryo implantation; and mRNA localization resulting in posttranscriptional regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; gonad; olfactory epithelium; and trigeminal ganglion. Human ortholog(s) of this gene implicated in gout. Orthologous to human A1CF (APOBEC1 complementation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 13.0), liver E18 (RPKM 9.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19; 19 C1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (31846156..31929765)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (31868756..31952365)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene protein kinase, cGMP-dependent, type I Neighboring gene STARR-seq mESC enhancer starr_45917 Neighboring gene STARR-seq mESC enhancer starr_45919 Neighboring gene STARR-seq mESC enhancer starr_45920 Neighboring gene RIKEN cDNA 8430431K14 gene Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45921 Neighboring gene STARR-seq mESC enhancer starr_45922 Neighboring gene STARR-positive B cell enhancer ABC_E7645 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene VISTA enhancer mm1654 Neighboring gene N-acylsphingosine amidohydrolase 2 Neighboring gene STARR-positive B cell enhancer ABC_E5695 Neighboring gene STARR-positive B cell enhancer ABC_E4274 Neighboring gene STARR-seq mESC enhancer starr_45930 Neighboring gene STARR-seq mESC enhancer starr_45932 Neighboring gene coiled-coil domain containing 111 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45936 Neighboring gene STARR-seq mESC enhancer starr_45939 Neighboring gene STARR-positive B cell enhancer ABC_E9456 Neighboring gene sphingomyelin synthase 1 Neighboring gene Sgms1 opposite strand transcript 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetically-biased fertilization in APOBEC1 complementation factor (A1cf) mutant mice. Hirose N, et al. Sci Rep, 2022 Aug 10. PMID 35948620, Free PMC Article
  2. Adiponectin receptor 1 variants contribute to hypertrophic cardiomyopathy that can be reversed by rapamycin. Dhandapany PS, et al. Sci Adv, 2021 Jan. PMID 33523960, Free PMC Article
  3. Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer. Blanc V, et al. J Clin Invest, 2021 Jan 4. PMID 33445170, Free PMC Article
  4. Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration. Mohamed TMA, et al. Cell, 2018 Mar 22. PMID 29502971, Free PMC Article
  5. Epitranscriptomic profiling across cell types reveals associations between APOBEC1-mediated RNA editing, gene expression outcomes, and cellular function. Rayon-Estrada V, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29167373, Free PMC Article

See all (471) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer.
    Title: Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer.
  2. The RNA-Binding Protein A1CF Regulates Hepatic Fructose and Glycerol Metabolism via Alternative RNA Splicing.
    Title: The RNA-Binding Protein A1CF Regulates Hepatic Fructose and Glycerol Metabolism via Alternative RNA Splicing.
  3. A1CF and RBM47 each function independently, yet interact in a tissue-specific manner, to regulate the activity and site selection of APOBEC1 dependent C-to-U RNA editing.
    Title: Apobec1 complementation factor (A1CF) and RBM47 interact in tissue-specific regulation of C to U RNA editing in mouse intestine and liver.
  4. Here, we show that partial loss of either APOBEC1 complementation factor (A1CF), the RNA-binding cofactor of APOBEC1 in RNA editing, or Argonaute 2 (AGO2), a key factor in the biogenesis of certain noncoding RNAs, modulates risk for TGCTs and testicular abnormalities in both parent-of-origin and conventional genetic manners.
    Title: Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bias.
  5. The observations demonstrate that A1CF does not act as the APOBEC1 complementation factor in vivo under normal physiological conditions and suggest new roles for A1CF, specifically within the male adult kidney.
    Title: APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo.
  6. Data show that the importance of ACF for modulating ApoB was supported by the finding that RNAi knockdown of ACF reduced ApoB secretion.
    Title: Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes.
  7. ACF regulates liver regeneration following partial hepatectomy at least in part by controlling the stability of IL-6 mRNA
    Title: Apobec-1 complementation factor modulates liver regeneration by post-transcriptional regulation of interleukin-6 mRNA stability.
  8. ACF plays a crucial role, which is independent of apobec-1 expression, in cell survival, particularly during early embryonic development
    Title: Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables enzyme-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytidine to uridine editing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cytidine to uridine editing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytidine to uridine editing ISO
Inferred from Sequence Orthology
more info
  
involved_in cytidine to uridine editing TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within embryo implantation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA localization resulting in post-transcriptional regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within mRNA modification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mRNA modification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA demethylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of apolipoprotein B mRNA editing enzyme complex ISO
Inferred from Sequence Orthology
more info
  
part_of apolipoprotein B mRNA editing enzyme complex TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA editing complex ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA editing complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
APOBEC1 complementation factor
Names
APOBEC-1 stimulating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081074.2 → NP_001074543.1  APOBEC1 complementation factor isoform 1

    See identical proteins and their annotated locations for NP_001074543.1

    Status: VALIDATED

    Source sequence(s)
    AC117816, AC125019
    Consensus CDS
    CCDS37959.1
    UniProtKB/Swiss-Prot
    E9QJS8, Q5FW55, Q5YD47, Q5YD48
    Related
    ENSMUSP00000075235.6, ENSMUST00000075838.8
    Conserved Domains (1) summary
    TIGR01648
    Location:2 → 595
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  2. NM_001365078.1 → NP_001352007.1  APOBEC1 complementation factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117816, AC125019
    Consensus CDS
    CCDS89374.1
    Related
    ENSMUSP00000153542.2, ENSMUST00000224304.2
    Conserved Domains (1) summary
    TIGR01648
    Location:2 → 587
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    31846156..31929765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318290.2 → XP_017173779.1  APOBEC1 complementation factor isoform X1

    Conserved Domains (1) summary
    TIGR01648
    Location:1 → 511
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5YD48.2 GenPept UniProtKB/Swiss-Prot:Q5YD48

Gene LinkOut

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