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MAMU-A3 major histocompatibility complex, class I, A [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 699243, updated on 20-Nov-2023

Summary

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Gene symbol
MAMU-A3
Gene description
major histocompatibility complex, class I, A
See related
Ensembl:ENSMMUG00000056914
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
A4; Mamu-A; Mamu-A1; Mamu-A4
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Genomic context

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Location:
chromosome: 4
Exon count:
9
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (140081101..140096282, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (30485003..30487789)

Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114677360 Neighboring gene uncharacterized LOC106997883 Neighboring gene HLA class I histocompatibility antigen, A-30 alpha chain-like Neighboring gene uncharacterized LOC114677362 Neighboring gene uncharacterized LOC114677363

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rhesus macaque inhibitory and activating KIR3D interact with Mamu-A-encoded ligands. Rosner C, et al. J Immunol, 2011 Feb 15. PMID 21257962
  2. MHC class I alleles influence set-point viral load and survival time in simian immunodeficiency virus-infected rhesus monkeys. Mühl T, et al. J Immunol, 2002 Sep 15. PMID 12218167
  3. The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype. Solomon C, et al. Immunogenetics, 2010 Jul. PMID 20480161, Free PMC Article
  4. MHC class I A region diversity and polymorphism in macaque species. Otting N, et al. Immunogenetics, 2007 May. PMID 17334754, Free PMC Article
  5. A high incidence of Shigella-induced arthritis in a primate species: major histocompatibility complex class I molecules associated with resistance and susceptibility, and their relationship to HLA-B27. Urvater JA, et al. Immunogenetics, 2000 Apr. PMID 10803844

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables peptide antigen binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
major histocompatibility complex, class I, A
Names
MHC class 1 protein
MHC class I antigen
MHC class I heavy chain antigen
MHC class I protein
putative HLA class I histocompatibility antigen, alpha chain H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171838.1 → NP_001165309.1  major histocompatibility complex, class I, A precursor

    See identical proteins and their annotated locations for NP_001165309.1

    Status: PROVISIONAL

    Source sequence(s)
    EF186797
    UniProtKB/TrEMBL
    A0A2H1MZN9, A2IBC8
    Conserved Domains (3) summary
    pfam00129
    Location:25 → 203
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:337 → 362
    MHC_I_C; MHC_I C-terminus
    cd21026
    Location:204 → 300
    IgC1_MHC_Ia_HLA-B; Class Ia major histocompatibility complex (MHC) immunoglobulin domain of human leukocyte antigen (HLA) B and similar proteins; member of the C1-set of Ig superfamily (IgSF) domains

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041757.1 Reference Mmul_10 Primary Assembly

    Range
    140081101..140096282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028846906.1 → XP_028702739.1  major histocompatibility complex, class I, A isoform X3

    Conserved Domains (2) summary
    cl08246
    Location:185 → 244
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:248 → 329
    Ig; Immunoglobulin domain

  2. XM_028846907.1 → XP_028702740.1  major histocompatibility complex, class I, A isoform X4

    UniProtKB/TrEMBL
    A0A5F8ABR2
    Conserved Domains (2) summary
    pfam00129
    Location:24 → 201
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:205 → 286
    Ig; Immunoglobulin domain

  3. XM_028846908.1 → XP_028702741.1  major histocompatibility complex, class I, A isoform X5

    Conserved Domains (3) summary
    cd07698
    Location:113 → 205
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam06623
    Location:244 → 270
    MHC_I_C; MHC_I C-terminus
    cl08246
    Location:24 → 112
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  4. XM_028846905.1 → XP_028702738.1  major histocompatibility complex, class I, A isoform X2

    UniProtKB/TrEMBL
    A0A0P1L5V1, A0A0P1LAK2, A0A1G4P149, A0A1G4P168, A0A1G4P170, A0A1G4P186, A0A1G4P1D1, A9XN16, F7F1S2
    Related
    ENSMMUP00000011542.4, ENSMMUT00000012304.4
    Conserved Domains (3) summary
    pfam00129
    Location:23 → 201
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    pfam06623
    Location:335 → 360
    MHC_I_C; MHC_I C-terminus
    cd21026
    Location:202 → 298
    IgC1_MHC_Ia_HLA-B; Class Ia major histocompatibility complex (MHC) immunoglobulin domain of human leukocyte antigen (HLA) B and similar proteins; member of the C1-set of Ig superfamily (IgSF) domains

  5. XM_028846904.1 → XP_028702737.1  major histocompatibility complex, class I, A isoform X1

    UniProtKB/TrEMBL
    A0A5K1IAH9
    Related
    ENSMMUP00000075342.1, ENSMMUT00000095232.1
    Conserved Domains (3) summary
    cd07698
    Location:205 → 297
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam06623
    Location:336 → 362
    MHC_I_C; MHC_I C-terminus
    pfam00129
    Location:24 → 201
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RNA

  1. XR_003728609.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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