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Prpf4 pre-mRNA processing factor 4 [ Mus musculus (house mouse) ]

Gene ID: 70052, updated on 23-Jun-2021

Summary

Official Symbol
Prpf4provided by MGI
Official Full Name
pre-mRNA processing factor 4provided by MGI
Primary source
MGI:MGI:1917302
See related
Ensembl:ENSMUSG00000066148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI874830; AW047464; bN189G18.1; 1600015H11Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.2), limb E14.5 (RPKM 6.9) and 28 other tissues See more
Orthologs
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Genomic context

See Prpf4 in Genome Data Viewer
Location:
4; 4 B3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62327002..62345227)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62408762..62426990)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (62069817..62088024)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene FK506 binding protein 15 Neighboring gene solute carrier family 31, member 1 Neighboring gene cell division cycle 26 Neighboring gene ring finger protein 183 Neighboring gene predicted gene, 30589 Neighboring gene WD repeat domain 31

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117717

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables U4 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables U6 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of U4/U6 snRNP ISO
Inferred from Sequence Orthology
more info
 
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal snRNP complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
U4/U6 small nuclear ribonucleoprotein Prp4
Names
U4/U6 snRNP 60 kDa protein
WD splicing factor Prp4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027297.3NP_081573.1  U4/U6 small nuclear ribonucleoprotein Prp4

    See identical proteins and their annotated locations for NP_081573.1

    Status: VALIDATED

    Source sequence(s)
    AK167216, AL732548, AL732594
    Consensus CDS
    CCDS18239.1
    UniProtKB/Swiss-Prot
    Q9DAW6
    UniProtKB/TrEMBL
    Q059T9
    Related
    ENSMUSP00000081572.4, ENSMUST00000084524.4
    Conserved Domains (3) summary
    smart00500
    Location:102140
    SFM; Splicing Factor Motif, present in Prp18 and Pr04
    cd00200
    Location:232518
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:233270
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    62327002..62345227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253770.2XP_030109630.1  U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1

    Conserved Domains (2) summary
    cd00200
    Location:8276
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4278
    7WD40; WD40 repeat [structural motif]
  2. XM_006538249.4XP_006538312.1  U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1

    Conserved Domains (2) summary
    cd00200
    Location:8276
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:4278
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_390341.3 RNA Sequence

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