U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DKK3 dickkopf WNT signaling pathway inhibitor 3 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 701549, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
DKK3provided by VGNC
Official Full Name
dickkopf WNT signaling pathway inhibitor 3provided by VGNC
Primary source
VGNC:VGNC:71804
See related
Ensembl:ENSMMUG00000022862
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See DKK3 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
12
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (53614484..53661461)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (54413130..54459507)

Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene parvin alpha Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing 2 Neighboring gene uncharacterized LOC114672320 Neighboring gene ubiquitin specific peptidase 47 Neighboring gene uncharacterized LOC114672335 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 18

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dickkopf homolog 3 (DKK3) plays a crucial role upstream of WNT/β-CATENIN signaling for Sertoli cell mediated regulation of spermatogenesis. Das DS, et al. PLoS One, 2013. PMID 23667645, Free PMC Article
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This is the first report of role of DKK3 in the testis and DKK3 mediated regulation of spermatogenesis via WNT-4/beta-CATENIN modulation.
    Title: Dickkopf homolog 3 (DKK3) plays a crucial role upstream of WNT/β-CATENIN signaling for Sertoli cell mediated regulation of spermatogenesis.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables co-receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
dickkopf-related protein 3
Names
dickkopf 3 homolog
dickkopf homolog 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001265749.1 → NP_001252678.1  dickkopf-related protein 3 precursor

    See identical proteins and their annotated locations for NP_001252678.1

    Status: PROVISIONAL

    Source sequence(s)
    JV667376
    UniProtKB/TrEMBL
    F6WN85, F6WNA0, H9EWS7, I0FKV6
    Related
    ENSMMUP00000030109.4, ENSMMUT00000032184.4
    Conserved Domains (2) summary
    pfam06607
    Location:208 → 273
    Prokineticin
    pfam04706
    Location:147 → 196
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041767.1 Reference Mmul_10 Primary Assembly

    Range
    53614484..53661461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028832590.1 → XP_028688423.1  dickkopf-related protein 3 isoform X2

    UniProtKB/TrEMBL
    F6WN85, F6WNA0, H9EWS7, I0FKV6
    Related
    ENSMMUP00000030106.2, ENSMMUT00000032181.4
    Conserved Domains (2) summary
    pfam06607
    Location:208 → 273
    Prokineticin
    pfam04706
    Location:147 → 196
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

  2. XM_028832592.1 → XP_028688425.1  dickkopf-related protein 3 isoform X2

    UniProtKB/TrEMBL
    F6WN85, F6WNA0, H9EWS7, I0FKV6
    Conserved Domains (2) summary
    pfam06607
    Location:208 → 273
    Prokineticin
    pfam04706
    Location:147 → 196
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

  3. XM_015114739.2 → XP_014970225.2  dickkopf-related protein 3 isoform X1

    Conserved Domains (2) summary
    pfam06607
    Location:304 → 369
    Prokineticin
    pfam04706
    Location:243 → 292
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

  4. XM_015114740.2 → XP_014970226.1  dickkopf-related protein 3 isoform X2

    UniProtKB/TrEMBL
    F6WN85, F6WNA0, H9EWS7, I0FKV6
    Conserved Domains (2) summary
    pfam06607
    Location:208 → 273
    Prokineticin
    pfam04706
    Location:147 → 196
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region

  5. XM_028832591.1 → XP_028688424.1  dickkopf-related protein 3 isoform X2

    UniProtKB/TrEMBL
    F6WN85, F6WNA0, H9EWS7, I0FKV6
    Conserved Domains (2) summary
    pfam06607
    Location:208 → 273
    Prokineticin
    pfam04706
    Location:147 → 196
    Dickkopf_N; Dickkopf N-terminal cysteine-rich region
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.