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TFDP1 transcription factor Dp-1 [ Homo sapiens (human) ]

Gene ID: 7027, updated on 7-Apr-2024

Summary

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Official Symbol
TFDP1provided by HGNC
Official Full Name
transcription factor Dp-1provided by HGNC
Primary source
HGNC:HGNC:11749
See related
Ensembl:ENSG00000198176 MIM:189902; AllianceGenome:HGNC:11749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP1; DILC; Dp-1; DRTF1
Summary
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]
Expression
Ubiquitous expression in bone marrow (RPKM 54.1), lymph node (RPKM 31.4) and 24 other tissues See more
Orthologs
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Genomic context

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See TFDP1 in Genome Data Viewer
Location:
13q34
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (113584688..113641473)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (112843768..112900540)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114239003..114295788)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene defective in cullin neddylation 1 domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5548 Neighboring gene RNA, U1 small nuclear 16, pseudogene Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:114192765-114192953 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:114195260-114196459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114200259-114201002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114206049-114206550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114236917-114237890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114237891-114238862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114240840-114241440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114251630-114252130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114268207-114268770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114267642-114268206 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114269335-114269898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114269899-114270462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114271027-114271590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114271591-114272153 Neighboring gene uncharacterized LOC124903219 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114279174-114280373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114305936-114306560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114306561-114307185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114311832-114312332 Neighboring gene ATPase H+/K+ transporting subunit beta Neighboring gene G protein-coupled receptor kinase 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:114426222-114426826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114426827-114427432 Neighboring gene basic salivary proline-rich protein 4-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114446225-114446726 Neighboring gene long intergenic non-protein coding RNA 552

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of the TFDP1 gene in the endometrium of women with deep infiltrating endometriosis. Jibrim RLM, et al. Gynecol Endocrinol, 2019 Jun. PMID 30638096
  2. Long non‑coding RNA DILC is involved in sepsis by modulating the signaling pathway of the interleukin‑6/signal transducer and activator of transcription 3/Toll‑like receptor 4 axis. Huang W, et al. Mol Med Rep, 2018 Dec. PMID 30365067
  3. Dysregulation of TFDP1 and of the cell cycle pathway in high-grade glioblastoma multiforme: a bioinformatic analysis. Lu X, et al. Genet Mol Res, 2016 Jun 10. PMID 27323154
  4. Next-generation sequencing of colorectal cancers in chinese: identification of a recurrent frame-shift and gain-of-function Indel mutation in the TFDP1 gene. Chen C, et al. OMICS, 2014 Oct. PMID 25133581, Free PMC Article
  5. Identification of significant regions of transcription factor DP-1 (TFDP-1) involved in stability/instability of the protein. Arakawa T, et al. Biochem Biophys Res Commun, 2010 Jun 25. PMID 20513349

See all (114) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer.
    Title: Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer.
  2. miR-4711-5p regulates cancer stemness and cell cycle progression via KLF5, MDM2 and TFDP1 in colon cancer cells.
    Title: miR-4711-5p regulates cancer stemness and cell cycle progression via KLF5, MDM2 and TFDP1 in colon cancer cells.
  3. It uncovered E2F1 and TFDP1 as transport substrates of KPNA2 being retained in the cytoplasm upon KPNA2 ablation, thereby resulting in reduced STMN1 expression.
    Title: Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer.
  4. We observed a downregulation of TFDP1 in the endometrium cells of women with deep infiltrating endometriosis when compared to the controls
    Title: Expression of the TFDP1 gene in the endometrium of women with deep infiltrating endometriosis.
  5. DILC may mediate the crosstalk between the cascades of IL6/STAT3 and TNFalpha signaling, indicating that DILC may act as a prognostic biomarker of sepsis, and may serve as a potential therapeutic target for the treatment of sepsis.
    Title: Long non‑coding RNA DILC is involved in sepsis by modulating the signaling pathway of the interleukin‑6/signal transducer and activator of transcription 3/Toll‑like receptor 4 axis.
  6. COMMD9 participates in TFDP1/E2F1 activation and plays a critical role in non-small cell lung cancer.
    Title: COMMD9 promotes TFDP1/E2F1 transcriptional activity via interaction with TFDP1 in non-small cell lung cancer.
  7. Here, the authors show that an acidic region of DP1, whose function has remained elusive, binds to the plekstrin homology (PH) domain of the p62 subunit of TFIIH that contributes to transcriptional activation.
    Title: The Interaction Mode of the Acidic Region of the Cell Cycle Transcription Factor DP1 with TFIIH.
  8. role for E2F1 and TFDP1 in the transcriptional regulation of PITX1 in articular chondrocytes
    Title: E2F1 and TFDP1 Regulate PITX1 Expression in Normal and Osteoarthritic Articular Chondrocytes.
  9. According to our study results, the gene TFDP1 and the cell cycle pathway are strongly associated with high-grade glioblastoma multiforme (GBM); this result may provide new insights into the pathogenesis of GBM.
    Title: Dysregulation of TFDP1 and of the cell cycle pathway in high-grade glioblastoma multiforme: a bioinformatic analysis.
  10. Amplification of CUL4A, IRS2, and TFDP1 genes showed a significant difference in disease-free survival by both univariate and multivariate survival analyses in intrahepatic cholangiocarcinoma.
    Title: Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anoikis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in epidermis development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of fat cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of RNA polymerase II transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of Rb-E2F complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of Rb-E2F complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription factor Dp-1
Names
DRTF1-polypeptide 1
E2F dimerization partner 1
E2F-related transcription factor
down-regulated in liver cancer stem cells

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029909.1 RefSeqGene

    Range
    5066..61786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007111.5 → NP_009042.1  transcription factor Dp-1

    See identical proteins and their annotated locations for NP_009042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL442125, BC011685
    Consensus CDS
    CCDS9538.1
    UniProtKB/Swiss-Prot
    B4DLQ9, Q14186, Q5JSB4, Q8IZL5
    Related
    ENSP00000364519.4, ENST00000375370.10
    Conserved Domains (3) summary
    cd14458
    Location:198 → 244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:113 → 193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200 → 338
    DP; Transcription factor DP

RNA

  1. NR_026580.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK297114, AL442125, CD623680

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    113584688..113641473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020717.2 → XP_016876206.1  transcription factor Dp-1 isoform X1

  2. XM_005268327.2 → XP_005268384.1  transcription factor Dp-1 isoform X3

    See identical proteins and their annotated locations for XP_005268384.1

    UniProtKB/Swiss-Prot
    B4DLQ9, Q14186, Q5JSB4, Q8IZL5
    Conserved Domains (3) summary
    cd14458
    Location:198 → 244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:113 → 193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200 → 338
    DP; Transcription factor DP

  3. XM_017020718.2 → XP_016876207.1  transcription factor Dp-1 isoform X4

    Conserved Domains (3) summary
    cd14458
    Location:198 → 244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:113 → 193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200 → 338
    DP; Transcription factor DP

  4. XM_017020719.3 → XP_016876208.1  transcription factor Dp-1 isoform X6

    Conserved Domains (3) summary
    cd14458
    Location:198 → 244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:113 → 193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200 → 335
    DP; Transcription factor DP

  5. XM_047430562.1 → XP_047286518.1  transcription factor Dp-1 isoform X3

    UniProtKB/Swiss-Prot
    B4DLQ9, Q14186, Q5JSB4, Q8IZL5

  6. XM_047430566.1 → XP_047286522.1  transcription factor Dp-1 isoform X3

    UniProtKB/Swiss-Prot
    B4DLQ9, Q14186, Q5JSB4, Q8IZL5

  7. XM_047430569.1 → XP_047286525.1  transcription factor Dp-1 isoform X4

  8. XM_047430554.1 → XP_047286510.1  transcription factor Dp-1 isoform X1

  9. XM_047430561.1 → XP_047286517.1  transcription factor Dp-1 isoform X2

  10. XM_047430570.1 → XP_047286526.1  transcription factor Dp-1 isoform X4

  11. XM_047430575.1 → XP_047286531.1  transcription factor Dp-1 isoform X6

  12. XM_047430564.1 → XP_047286520.1  transcription factor Dp-1 isoform X3

    UniProtKB/Swiss-Prot
    B4DLQ9, Q14186, Q5JSB4, Q8IZL5

  13. XM_047430568.1 → XP_047286524.1  transcription factor Dp-1 isoform X4

  14. XM_047430558.1 → XP_047286514.1  transcription factor Dp-1 isoform X1

  15. XM_047430573.1 → XP_047286529.1  transcription factor Dp-1 isoform X6

  16. XM_047430560.1 → XP_047286516.1  transcription factor Dp-1 isoform X1

  17. XM_047430574.1 → XP_047286530.1  transcription factor Dp-1 isoform X6

  18. XM_005268328.3 → XP_005268385.1  transcription factor Dp-1 isoform X4

    See identical proteins and their annotated locations for XP_005268385.1

    Conserved Domains (3) summary
    cd14458
    Location:198 → 244
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:113 → 193
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:200 → 338
    DP; Transcription factor DP

  19. XM_047430557.1 → XP_047286513.1  transcription factor Dp-1 isoform X1

  20. XM_047430559.1 → XP_047286515.1  transcription factor Dp-1 isoform X1

  21. XM_047430563.1 → XP_047286519.1  transcription factor Dp-1 isoform X3

    UniProtKB/Swiss-Prot
    B4DLQ9, Q14186, Q5JSB4, Q8IZL5

  22. XM_047430567.1 → XP_047286523.1  transcription factor Dp-1 isoform X4

  23. XM_047430572.1 → XP_047286528.1  transcription factor Dp-1 isoform X6

  24. XM_047430571.1 → XP_047286527.1  transcription factor Dp-1 isoform X5

  25. XM_047430576.1 → XP_047286532.1  transcription factor Dp-1 isoform X7

  26. XM_047430577.1 → XP_047286533.1  transcription factor Dp-1 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    112843768..112900540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374884.1 → XP_054230859.1  transcription factor Dp-1 isoform X1

  2. XM_054374890.1 → XP_054230865.1  transcription factor Dp-1 isoform X3

    UniProtKB/Swiss-Prot
    B4DLQ9, Q14186, Q5JSB4, Q8IZL5

  3. XM_054374896.1 → XP_054230871.1  transcription factor Dp-1 isoform X4

  4. XM_054374902.1 → XP_054230877.1  transcription factor Dp-1 isoform X6

  5. XM_054374892.1 → XP_054230867.1  transcription factor Dp-1 isoform X3

    UniProtKB/Swiss-Prot
    B4DLQ9, Q14186, Q5JSB4, Q8IZL5

  6. XM_054374893.1 → XP_054230868.1  transcription factor Dp-1 isoform X3

    UniProtKB/Swiss-Prot
    B4DLQ9, Q14186, Q5JSB4, Q8IZL5

  7. XM_054374882.1 → XP_054230857.1  transcription factor Dp-1 isoform X1

  8. XM_054374888.1 → XP_054230863.1  transcription factor Dp-1 isoform X2

  9. XM_054374899.1 → XP_054230874.1  transcription factor Dp-1 isoform X4

  10. XM_054374905.1 → XP_054230880.1  transcription factor Dp-1 isoform X6

  11. XM_054374898.1 → XP_054230873.1  transcription factor Dp-1 isoform X4

  12. XM_054374891.1 → XP_054230866.1  transcription factor Dp-1 isoform X3

    UniProtKB/Swiss-Prot
    B4DLQ9, Q14186, Q5JSB4, Q8IZL5

  13. XM_054374897.1 → XP_054230872.1  transcription factor Dp-1 isoform X4

  14. XM_054374885.1 → XP_054230860.1  transcription factor Dp-1 isoform X1

  15. XM_054374903.1 → XP_054230878.1  transcription factor Dp-1 isoform X6

  16. XM_054374887.1 → XP_054230862.1  transcription factor Dp-1 isoform X1

  17. XM_054374904.1 → XP_054230879.1  transcription factor Dp-1 isoform X6

  18. XM_054374894.1 → XP_054230869.1  transcription factor Dp-1 isoform X4

  19. XM_054374883.1 → XP_054230858.1  transcription factor Dp-1 isoform X1

  20. XM_054374886.1 → XP_054230861.1  transcription factor Dp-1 isoform X1

  21. XM_054374889.1 → XP_054230864.1  transcription factor Dp-1 isoform X3

    UniProtKB/Swiss-Prot
    B4DLQ9, Q14186, Q5JSB4, Q8IZL5

  22. XM_054374895.1 → XP_054230870.1  transcription factor Dp-1 isoform X4

  23. XM_054374901.1 → XP_054230876.1  transcription factor Dp-1 isoform X6

  24. XM_054374900.1 → XP_054230875.1  transcription factor Dp-1 isoform X5

  25. XM_054374906.1 → XP_054230881.1  transcription factor Dp-1 isoform X7

  26. XM_054374907.1 → XP_054230882.1  transcription factor Dp-1 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14186.1 GenPept UniProtKB/Swiss-Prot:Q14186

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