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Gprc5c G protein-coupled receptor, family C, group 5, member C [ Mus musculus (house mouse) ]

Gene ID: 70355, updated on 11-Apr-2024

Summary

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Official Symbol
Gprc5cprovided by MGI
Official Full Name
G protein-coupled receptor, family C, group 5, member Cprovided by MGI
Primary source
MGI:MGI:1917605
See related
Ensembl:ENSMUSG00000051043 AllianceGenome:MGI:1917605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Raig3; 1110028I06Rik; 3200002M13Rik
Summary
Predicted to enable protein kinase activator activity. Predicted to be involved in G protein-coupled receptor signaling pathway and visual perception. Predicted to act upstream of or within signal transduction. Located in mitochondrion. Is expressed in embryo endoderm; liver; lung; and metanephros. Orthologous to human GPRC5C (G protein-coupled receptor class C group 5 member C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 60.6), genital fat pad adult (RPKM 25.6) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 80.54 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (114741976..114763443)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (114851150..114872617)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 19A Neighboring gene BTB domain containing 17 Neighboring gene G protein-coupled receptor 142 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:114734569-114734722 Neighboring gene STARR-seq mESC enhancer starr_31138 Neighboring gene CD300A molecule Neighboring gene CD300 molecule like family member B Neighboring gene predicted gene 11699

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identifying the localization and exploring a functional role for Gprc5c in the kidney. Rajkumar P, et al. FASEB J, 2018 Apr. PMID 29196502, Free PMC Article
  2. Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells. Amisten S, et al. Endocr J, 2017 Mar 31. PMID 28228611
  3. Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy. Cabezas-Wallscheid N, et al. Cell, 2017 May 18. PMID 28479188
  4. Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice. Sano T, et al. Biochem Biophys Res Commun, 2011 Sep 2. PMID 21840300
  5. The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex. Kurabayashi N, et al. Development, 2013 Nov. PMID 24089469

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPRC5C regulates the composition of cilia in the olfactory system.
    Title: GPRC5C regulates the composition of cilia in the olfactory system.
  2. G-protein coupled receptor 5C (GPRC5C) is required for osteoblast differentiation and responds to EZH2 inhibition and multiple osteogenic signals.
    Title: G-protein coupled receptor 5C (GPRC5C) is required for osteoblast differentiation and responds to EZH2 inhibition and multiple osteogenic signals.
  3. The G protein-coupled receptor GPRC5C is a saccharide sensor with a novel 'off' response.
    Title: The G protein-coupled receptor GPRC5C is a saccharide sensor with a novel 'off' response.
  4. Gprc5c KO mice have altered acid-base homeostasis and reduced NHE3 activity in the kidney.
    Title: Identifying the localization and exploring a functional role for Gprc5c in the kidney.
  5. Data suggest that agents (such as all-trans retinoic acid) that activate Gprc5c restore and/or maintain functional insulin-secreting cells; Gprc5c appears to play role in regulation of expression of genes controlling apoptosis, cell survival, and cell proliferation in insulin-secreting cells.
    Title: Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells.
  6. GPRC5C does not affect behavior, though it has a high sequence similarity to GPRC5B.
    Title: Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC6786, MGC11976

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sevenless binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular exosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
G-protein coupled receptor family C group 5 member C
Names
RAIG-3
retinoic acid inducible protein 3
retinoic acid-induced gene 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110337.1 → NP_001103807.1  G-protein coupled receptor family C group 5 member C isoform a precursor

    See identical proteins and their annotated locations for NP_001103807.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK128950, AW536310, BY003041, BY108149, CO425185
    Consensus CDS
    CCDS48978.1
    UniProtKB/Swiss-Prot
    Q8K0H0, Q8K3J9
    UniProtKB/TrEMBL
    I7HPW4
    Related
    ENSMUSP00000061760.6, ENSMUST00000053361.12
    Conserved Domains (1) summary
    cd15277
    Location:47 → 304
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

  2. NM_001110338.1 → NP_001103808.1  G-protein coupled receptor family C group 5 member C isoform b precursor

    See identical proteins and their annotated locations for NP_001103808.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK003946, AK128950, AL669969, BI134748
    Consensus CDS
    CCDS25612.1
    UniProtKB/Swiss-Prot
    Q8K0H0, Q8K3J9
    UniProtKB/TrEMBL
    J3JS84
    Related
    ENSMUSP00000136702.2, ENSMUST00000177952.8
    Conserved Domains (1) summary
    pfam00003
    Location:91 → 144
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

  3. NM_147217.3 → NP_671750.2  G-protein coupled receptor family C group 5 member C isoform b precursor

    See identical proteins and their annotated locations for NP_671750.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK003946, AK128950, BB871704, BI134748
    Consensus CDS
    CCDS25612.1
    UniProtKB/Swiss-Prot
    Q8K0H0, Q8K3J9
    UniProtKB/TrEMBL
    J3JS84
    Related
    ENSMUSP00000021071.8, ENSMUST00000021071.14
    Conserved Domains (1) summary
    pfam00003
    Location:91 → 144
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    114741976..114763443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534164.4 → XP_006534227.1  G-protein coupled receptor family C group 5 member C isoform X2

    See identical proteins and their annotated locations for XP_006534227.1

    UniProtKB/Swiss-Prot
    Q8K0H0, Q8K3J9
    UniProtKB/TrEMBL
    I7HPW4
    Conserved Domains (1) summary
    cd15277
    Location:47 → 304
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

  2. XM_030246296.2 → XP_030102156.2  G-protein coupled receptor family C group 5 member C isoform X1

    UniProtKB/Swiss-Prot
    Q8K0H0, Q8K3J9
    Conserved Domains (1) summary
    cd15277
    Location:80 → 337
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

  3. XM_006534163.4 → XP_006534226.1  G-protein coupled receptor family C group 5 member C isoform X2

    See identical proteins and their annotated locations for XP_006534226.1

    UniProtKB/Swiss-Prot
    Q8K0H0, Q8K3J9
    UniProtKB/TrEMBL
    I7HPW4
    Conserved Domains (1) summary
    cd15277
    Location:47 → 304
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

  4. XM_006534162.1 → XP_006534225.1  G-protein coupled receptor family C group 5 member C isoform X2

    See identical proteins and their annotated locations for XP_006534225.1

    UniProtKB/Swiss-Prot
    Q8K0H0, Q8K3J9
    UniProtKB/TrEMBL
    I7HPW4
    Conserved Domains (1) summary
    cd15277
    Location:47 → 304
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C

  5. XM_006534161.5 → XP_006534224.1  G-protein coupled receptor family C group 5 member C isoform X2

    See identical proteins and their annotated locations for XP_006534224.1

    UniProtKB/Swiss-Prot
    Q8K0H0, Q8K3J9
    UniProtKB/TrEMBL
    I7HPW4
    Conserved Domains (1) summary
    cd15277
    Location:47 → 304
    7tmC_RAIG3_GPRC5C; retinoic acid-inducible orphan G-protein-coupled receptor 3; class C family of seven-transmembrane G protein-coupled receptors, group 5, member C
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3J9.2 GenPept UniProtKB/Swiss-Prot:Q8K3J9

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