Gtpbp3 GTP binding protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gtpbp3provided by MGI
Official Full Name: GTP binding protein 3provided by MGI
Primary source: MGI:MGI:1917609
See related: Ensembl:ENSMUSG00000007610 AllianceGenome:MGI:1917609
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410009F13Rik
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in tRNA methylation and tRNA wobble uridine modification. Predicted to act upstream of or within tRNA processing. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 23. Orthologous to human GTPBP3 (GTP binding protein 3, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 16.6), adrenal adult (RPKM 15.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.43 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (71938788..71952268)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (71486144..71499624)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These observations suggest that the mouse Gtpbp3 is an evolutionarily conserved mitochondrial GTP-binding protein involved in the tRNA modification.
Title: Identification and characterization of mouse GTPBP3 gene encoding a mitochondrial GTP-binding protein involved in tRNA modification.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA modification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA wobble uridine modification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tRNA modification GTPase GTPBP3, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032544.4 → NP_115933.2 tRNA modification GTPase GTPBP3, mitochondrial precursor

See identical proteins and their annotated locations for NP_115933.2

Status: VALIDATED

Source sequence(s)

AC127416

Consensus CDS

CCDS40384.1

UniProtKB/Swiss-Prot

Q58E73, Q923K4, Q99M99

UniProtKB/TrEMBL

B2RRS4, E9PWV7

Related

ENSMUSP00000007754.7, ENSMUST00000007754.13

Conserved Domains (3) summary

cd04164
Location:248 → 416

trmE; trmE is a tRNA modification GTPase

PRK05291
Location:35 → 492

trmE; tRNA modification GTPase TrmE; Reviewed

pfam10396
Location:35 → 152

TrmE_N; GTP-binding protein TrmE N-terminus

RNA

NR_157144.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC127416
NR_157145.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC127416

Related

ENSMUST00000095259.10
NR_157146.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AK046330, BY287260, BY588239
NR_157147.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

BC055716, BY287260

Related

ENSMUST00000127741.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

71938788..71952268

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509737.4 → XP_006509800.1 tRNA modification GTPase GTPBP3, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006509800.1

Conserved Domains (1) summary

PRK05291
Location:35 → 323

trmE; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE