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Derl3 Der1-like domain family, member 3 [ Mus musculus (house mouse) ]

Gene ID: 70377, updated on 16-Oct-2021

Summary

Official Symbol
Derl3provided by MGI
Official Full Name
Der1-like domain family, member 3provided by MGI
Primary source
MGI:MGI:1917627
See related
Ensembl:ENSMUSG00000009092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IZP6; derlin-3; 1810006I20Rik; 1810063P04Rik
Expression
Biased expression in ovary adult (RPKM 82.9), genital fat pad adult (RPKM 42.8) and 8 other tissues See more
Orthologs
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Genomic context

See Derl3 in Genome Data Viewer
Location:
10; 10 C1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75729232..75731775)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75893398..75895941)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (75356143..75358686)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40697 Neighboring gene macrophage migration inhibitory factor (glycosylation-inhibiting factor) Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene matrix metallopeptidase 11

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Clone Names

  • MGC118672, MGC144274, MGC144275

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signal recognition particle binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-specific protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of Hrd1p ubiquitin ligase ERAD-L complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
derlin-3
Names
degradation in endoplasmic reticulum protein 3
der1-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358983.1NP_001345912.1  derlin-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB047555, AK007948, BC099615, BE952795
    Consensus CDS
    CCDS88024.1
    Related
    ENSMUSP00000151623.2, ENSMUST00000217811.2
    Conserved Domains (1) summary
    pfam04511
    Location:13201
    DER1; Der1-like family
  2. NM_001358984.1NP_001345913.1  derlin-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AB047555, AC142499, AK007348, AK007948, BC099615, BE952795
    Conserved Domains (1) summary
    pfam04511
    Location:13180
    DER1; Der1-like family
  3. NM_001358985.1NP_001345914.1  derlin-3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AB047555, AK007348, BE952795
    Conserved Domains (1) summary
    cl21536
    Location:13161
    Rhomboid; Rhomboid family
  4. NM_024440.2NP_077760.1  derlin-3 isoform 1

    See identical proteins and their annotated locations for NP_077760.1

    Status: VALIDATED

    Source sequence(s)
    AC142499
    Consensus CDS
    CCDS23935.1
    UniProtKB/Swiss-Prot
    Q9D8K3
    UniProtKB/TrEMBL
    Q14C34
    Related
    ENSMUSP00000009236.5, ENSMUST00000009236.6
    Conserved Domains (1) summary
    pfam04511
    Location:13202
    DER1; Der1-like family

RNA

  1. NR_152573.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AB047555, BC099615, BE952795
  2. NR_152574.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AB047555, AK007348, BE952795
    Related
    ENSMUST00000218506.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    75729232..75731775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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