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Asb12 ankyrin repeat and SOCS box-containing 12 [ Mus musculus (house mouse) ]

Gene ID: 70392, updated on 5-Mar-2024

Summary

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Official Symbol
Asb12provided by MGI
Official Full Name
ankyrin repeat and SOCS box-containing 12provided by MGI
Primary source
MGI:MGI:1917642
See related
Ensembl:ENSMUSG00000031204 AllianceGenome:MGI:1917642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asb-12; 2310036C05Rik
Summary
Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB12 (ankyrin repeat and SOCS box containing 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 3.3), heart adult (RPKM 3.0) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X C3; X 41.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (94513125..94601610, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (95469527..95558004, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene APC membrane recruitment 1 Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47573 Neighboring gene STARR-seq mESC enhancer starr_47574 Neighboring gene zinc finger, C4H2 domain containing Neighboring gene adenylosuccinate lyase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Testis-enriched Asb12 is not required for spermatogenesis and fertility in mice. Zhang R, et al. Transl Androl Urol, 2022 Feb. PMID 35280661, Free PMC Article
  2. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
  3. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC130200

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 12
Names
ankyrin repeat and SOCS box-containing protein 12
ankyrin repeat domain-containing SOCS box protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313743.1 → NP_001300672.1  ankyrin repeat and SOCS box protein 12

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AL671765, BC107257
    Consensus CDS
    CCDS30283.1
    UniProtKB/Swiss-Prot
    Q9D738
    UniProtKB/TrEMBL
    Q3KNI9
    Conserved Domains (4) summary
    PHA02875
    Location:25 → 259
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:66 → 94
    ANK; ANK repeat [structural motif]
    pfam07525
    Location:268 → 306
    SOCS_box; SOCS box
    pfam12796
    Location:68 → 159
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_080858.3 → NP_543134.1  ankyrin repeat and SOCS box protein 12

    See identical proteins and their annotated locations for NP_543134.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AL671765
    Consensus CDS
    CCDS30283.1
    UniProtKB/Swiss-Prot
    Q9D738
    UniProtKB/TrEMBL
    Q3KNI9
    Related
    ENSMUSP00000033549.3, ENSMUST00000033549.3
    Conserved Domains (4) summary
    PHA02875
    Location:25 → 259
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:66 → 94
    ANK; ANK repeat [structural motif]
    pfam07525
    Location:268 → 306
    SOCS_box; SOCS box
    pfam12796
    Location:68 → 159
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    94513125..94601610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247674.4 → XP_011245976.1  ankyrin repeat and SOCS box protein 12 isoform X1

    See identical proteins and their annotated locations for XP_011245976.1

    UniProtKB/Swiss-Prot
    Q9D738
    UniProtKB/TrEMBL
    Q3KNI9
    Conserved Domains (4) summary
    PHA02875
    Location:25 → 259
    PHA02875; ankyrin repeat protein; Provisional
    sd00045
    Location:66 → 94
    ANK; ANK repeat [structural motif]
    pfam07525
    Location:268 → 306
    SOCS_box; SOCS box
    pfam12796
    Location:68 → 159
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D738.1 GenPept UniProtKB/Swiss-Prot:Q9D738

Gene LinkOut

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