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Tekt5 tektin 5 [ Mus musculus (house mouse) ]

Gene ID: 70426, updated on 11-Apr-2024

Summary

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Official Symbol
Tekt5provided by MGI
Official Full Name
tektin 5provided by MGI
Primary source
MGI:MGI:1917676
See related
Ensembl:ENSMUSG00000039179 AllianceGenome:MGI:1917676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3300001K11Rik
Summary
Predicted to be involved in cilium assembly and cilium movement involved in cell motility. Located in sperm flagellum. Orthologous to human TEKT5 (tektin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 92.6) and cerebellum adult (RPKM 4.3) See more
Orthologs
human all
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Genomic context

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Location:
16 A1; 16 5.58 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10175816..10213319, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10357952..10395455, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1600 Neighboring gene predicted gene, 30724 Neighboring gene predicted gene, 41419 Neighboring gene STARR-positive B cell enhancer ABC_E10886 Neighboring gene nucleotide binding protein 1 Neighboring gene trans-golgi network vesicle protein 23A Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10469529-10469712 Neighboring gene predicted gene, 41420

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comprehensive Analysis of Mouse Cancer/Testis Antigen Functions in Cancer Cells and Roles of TEKT5 in Cancer Cells and Testicular Germ Cells. Aoki N, et al. Mol Cell Biol, 2019 Sep 1. PMID 31208979, Free PMC Article
  2. Characterization of a novel tektin member, TEKT5, in mouse sperm. Cao W, et al. J Androl, 2011 Jan-Feb. PMID 20378928, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results showed that TEKT5 controls tubulin stability to enhance the growth and survival of cancer cells and to promote sperm morphogenesis.
    Title: Comprehensive Analysis of Mouse Cancer/Testis Antigen Functions in Cancer Cells and Roles of TEKT5 in Cancer Cells and Testicular Germ Cells.
  2. TEKT5 protein was highly expressed in mouse spermatids and was localized in the flagellar accessory structures.
    Title: Characterization of a novel tektin member, TEKT5, in mouse sperm.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC144895

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axonemal A tubule inner sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tektin-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291001.2 → NP_001277930.1  tektin-5

    See identical proteins and their annotated locations for NP_001277930.1

    Status: VALIDATED

    Source sequence(s)
    AC154311
    Consensus CDS
    CCDS70683.1
    UniProtKB/Swiss-Prot
    D5HP88, G5E8A8, Q14BE9
    Related
    ENSMUSP00000046824.7, ENSMUST00000043415.13
    Conserved Domains (1) summary
    pfam03148
    Location:95 → 474
    Tektin; Tektin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    10175816..10213319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099275.1: Suppressed sequence

    Description
    NM_001099275.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5E8A8.1 GenPept UniProtKB/Swiss-Prot:G5E8A8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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