PTEN phosphatase and tensin homolog [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: PTENprovided by VGNC
Official Full Name: phosphatase and tensin homologprovided by VGNC
Primary source: VGNC:VGNC:106093
See related: Ensembl:ENSMMUG00000008431
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	9	NC_041762.1 (88124579..88228571)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	9	NC_027901.1 (83039157..83143283)

Chromosome 9 - NC_041762.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

G32419 (e-PCR)
- UniSTS:117006

PMC20246P1 (e-PCR)
- UniSTS:271890

STS-H71499 (e-PCR)
- UniSTS:5911

G19918 (e-PCR)
- UniSTS:77108

RH93626 (e-PCR)
- UniSTS:91967

RH66859 (e-PCR)
- UniSTS:92239

RH92455 (e-PCR)
- UniSTS:85842

RH122960 (e-PCR)
- UniSTS:135257

AFMA086WG9 (e-PCR)
- UniSTS:2163

PTEN_234 (e-PCR)
- UniSTS:468624

MARC_17017-17018:1023291848:1 (e-PCR)
- UniSTS:268185

SHGC-24026 (e-PCR)
- UniSTS:75675

Pten (e-PCR), detects polymorphism
- UniSTS:144288

WI-18385 (e-PCR)
- UniSTS:55210

STS-W73720 (e-PCR)
- UniSTS:71597

PMC154149P1 (e-PCR)
- UniSTS:271292

PMC88770P1 (e-PCR)
- UniSTS:273605

PMC88770P2 (e-PCR)
- UniSTS:273606

WI-22249 (e-PCR)
- UniSTS:2504

RH103681 (e-PCR)
- UniSTS:98006

A009C28 (e-PCR)
- UniSTS:74722

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell motility	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Names: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

NP_001247894.1

EC 3.1.3.16

EC 3.1.3.48

EC 3.1.3.67

XP_015003099.1

EC 3.1.3.16

EC 3.1.3.48

EC 3.1.3.67

XP_028709222.1

EC 3.1.3.16

EC 3.1.3.48

EC 3.1.3.67

XP_028709223.1

EC 3.1.3.16

EC 3.1.3.48

EC 3.1.3.67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001260965.1 → NP_001247894.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

See identical proteins and their annotated locations for NP_001247894.1

Status: PROVISIONAL

Source sequence(s)

JV047745

UniProtKB/TrEMBL

A0A1D5QNK5, H9YWL4

Conserved Domains (2) summary

cd14509
Location:24 → 181

PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog

pfam10409
Location:188 → 349

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041762.1 Reference Mmul_10 Primary Assembly

Range

88124579..88228571

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_028853389.1 → XP_028709222.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1

UniProtKB/TrEMBL

A0A1D5QNK5

Related

ENSMMUP00000049631.2, ENSMMUT00000066226.2

Conserved Domains (2) summary

cd14509
Location:24 → 166

PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog

pfam10409
Location:173 → 334

PTEN_C2; C2 domain of PTEN tumor-suppressor protein
XM_015147613.2 → XP_015003099.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2

Conserved Domains (2) summary

pfam10409
Location:55 → 216

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl28904
Location:1 → 48

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_028853390.1 → XP_028709223.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X3

Conserved Domains (1) summary

pfam10409
Location:1 → 152

PTEN_C2; C2 domain of PTEN tumor-suppressor protein