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Zdhhc2 zinc finger, DHHC domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 70546, updated on 5-Mar-2024

Summary

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Official Symbol
Zdhhc2provided by MGI
Official Full Name
zinc finger, DHHC domain containing 2provided by MGI
Primary source
MGI:MGI:1923452
See related
Ensembl:ENSMUSG00000039470 AllianceGenome:MGI:1923452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DHHC-2; 5730415P04Rik; 6430583A19Rik
Summary
Enables palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation and protein localization to plasma membrane. Acts upstream of or within protein palmitoylation. Located in plasma membrane; postsynaptic recycling endosome; and recycling endosome membrane. Is integral component of plasma membrane. Is expressed in several structures, including early conceptus; genitourinary system; nervous system; pancreas tip epithelium; and retina. Orthologous to human ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 7.5), cortex adult (RPKM 6.3) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A4; 8 23.89 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (40876526..40946178)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40423485..40489592)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 20 Neighboring gene microRNA 7666 Neighboring gene mitochondrial calcium uptake family, member 3 Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene vacuolar protein sorting 37A Neighboring gene myotubularin related protein 7 Neighboring gene STARR-seq mESC enhancer starr_21271 Neighboring gene STARR-seq mESC enhancer starr_21272 Neighboring gene ADAM metallopeptidase domain 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vivo Screen Identifies Zdhhc2 as a Critical Regulator of Germinal Center B Cell Differentiation. Zhao R, et al. Front Immunol, 2020. PMID 32587588, Free PMC Article
  2. Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis. Zhou B, et al. Front Immunol, 2020. PMID 33488612, Free PMC Article
  3. The palmitoyl acyltransferase DHHC2 regulates recycling endosome exocytosis and synaptic potentiation through palmitoylation of AKAP79/150. Woolfrey KM, et al. J Neurosci, 2015 Jan 14. PMID 25589740, Free PMC Article
  4. The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain. Greaves J, et al. Mol Biol Cell, 2011 Jun 1. PMID 21471008, Free PMC Article
  5. Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein. Jia L, et al. J Biol Chem, 2011 Apr 15. PMID 21343290, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis.
    Title: Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis.
  2. In vivo Screen Identifies Zdhhc2 as a Critical Regulator of Germinal Center B Cell Differentiation.
    Title: In vivo Screen Identifies Zdhhc2 as a Critical Regulator of Germinal Center B Cell Differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC156396

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-myristoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-stearoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of AMPA glutamate receptor clustering ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endosome to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to membrane raft IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to membrane raft ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic recycling endosome ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC2
Names
acyltransferase ZDHHC2
zinc finger DHHC domain-containing protein 2
NP_001344178.1
NP_848482.1
XP_006509548.1
XP_036010172.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357249.1 → NP_001344178.1  palmitoyltransferase ZDHHC2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC118012
    Conserved Domains (1) summary
    pfam01529
    Location:6 → 127
    DHHC; DHHC palmitoyltransferase

  2. NM_178395.4 → NP_848482.1  palmitoyltransferase ZDHHC2 isoform 1

    See identical proteins and their annotated locations for NP_848482.1

    Status: VALIDATED

    Source sequence(s)
    AK017566, AK030662, BE989599
    Consensus CDS
    CCDS22252.1
    UniProtKB/Swiss-Prot
    P59267
    UniProtKB/TrEMBL
    A0JP44
    Related
    ENSMUSP00000041727.5, ENSMUST00000049389.11
    Conserved Domains (1) summary
    pfam01529
    Location:126 → 247
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    40876526..40946178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509485.5 → XP_006509548.1  palmitoyltransferase ZDHHC2 isoform X1

    See identical proteins and their annotated locations for XP_006509548.1

    UniProtKB/Swiss-Prot
    P59267
    UniProtKB/TrEMBL
    A0JP44
    Conserved Domains (1) summary
    pfam01529
    Location:126 → 247
    DHHC; DHHC palmitoyltransferase

  2. XM_036154279.1 → XP_036010172.1  palmitoyltransferase ZDHHC2 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:6 → 127
    DHHC; DHHC palmitoyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59267.1 GenPept UniProtKB/Swiss-Prot:P59267

Gene LinkOut

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