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Itprid2 ITPR interacting domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 70599, updated on 5-Mar-2024

Summary

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Official Symbol
Itprid2provided by MGI
Official Full Name
ITPR interacting domain containing 2provided by MGI
Primary source
MGI:MGI:1917849
See related
Ensembl:ENSMUSG00000027007 AllianceGenome:MGI:1917849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CS1; CS-1; KRAP; Ssfa2; SPAG13; mKIAA1927; 5730488C15Rik
Summary
Predicted to enable actin filament binding activity. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Orthologous to human ITPRID2 (ITPR interacting domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 10.2), small intestine adult (RPKM 10.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C3; 2 47.58 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (79419207..79503310)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (79588863..79672966)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54165 Neighboring gene predicted gene, 39867 Neighboring gene STARR-positive B cell enhancer ABC_E2625 Neighboring gene STARR-seq mESC enhancer starr_04937 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 1C Neighboring gene STARR-seq mESC enhancer starr_04938 Neighboring gene STARR-seq mESC enhancer starr_04939 Neighboring gene phosphodiesterase 1A, calmodulin-dependent Neighboring gene predicted gene, 54166

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pancreatic hypertrophy in Ki-ras-induced actin-interacting protein gene knockout mice. Miyasaka K, et al. Pancreas, 2011 Jan. PMID 21160370
  2. Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice. Fujimoto T, et al. PLoS One, 2009. PMID 19156225, Free PMC Article
  3. KRAS-induced actin-interacting protein: a potent target for obesity, diabetes and cancer. Fujimoto T, et al. Anticancer Res, 2011 Jul. PMID 21873152
  4. KRAS-induced actin-interacting protein is required for the proper localization of inositol 1,4,5-trisphosphate receptor in the epithelial cells. Fujimoto T, et al. Biochem Biophys Res Commun, 2011 Apr 8. PMID 21420385
  5. Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney. Fujimoto T, et al. Int J Mol Med, 2012 Dec. PMID 22992961, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KRAP physically associates with IP3 receptors and regulates their proper localization in the mucous cells and the chief cells of the stomach and in the proximal tubular cells of the kidneys.
    Title: Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney.
  2. KRAP-deficient mice show altered whole-body energy metabolism & resistance to diet-induced obesity and diabetes. Review.
    Title: KRAS-induced actin-interacting protein: a potent target for obesity, diabetes and cancer.
  3. KRAP is involved in the proper regulation of IP3R-mediated Ca2+ release.
    Title: KRAS-induced actin-interacting protein regulates inositol 1,4,5-trisphosphate-receptor-mediated calcium release.
  4. These findings demonstrate that KRAP physically associates with IP(3)R and regulates the proper localization of IP(3)R in the epithelial cells in vivo and cultured cells.
    Title: KRAS-induced actin-interacting protein is required for the proper localization of inositol 1,4,5-trisphosphate receptor in the epithelial cells.
  5. The lack and/or decrease in Ki-ras-induced actin-interacting protein level in the pancreas may promote the pancreatic growth and hypertrophy.
    Title: Pancreatic hypertrophy in Ki-ras-induced actin-interacting protein gene knockout mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein ITPRID2
Names
ITPR-interacting domain-containing protein 2
ki-ras-induced actin-interacting protein
sperm specific antigen 2
sperm-specific antigen 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080558.4 → NP_542125.3  protein ITPRID2

    See identical proteins and their annotated locations for NP_542125.3

    Status: VALIDATED

    Source sequence(s)
    BC079535, CF539296, CJ129385
    Consensus CDS
    CCDS16170.1
    UniProtKB/Swiss-Prot
    A2AQD4, A5D8Z6, Q08E80, Q14BJ9, Q544I3, Q68FN1, Q75WU7, Q8CH96, Q8VEF7, Q922B9
    UniProtKB/TrEMBL
    A2AQD6
    Related
    ENSMUSP00000107415.3, ENSMUST00000111785.9
    Conserved Domains (2) summary
    pfam14722
    Location:146 → 297
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
    pfam14723
    Location:861 → 1029
    SSFA2_C; Sperm-specific antigen 2 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    79419207..79503310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162564.1 → XP_036018457.1  protein ITPRID2 isoform X1

    UniProtKB/Swiss-Prot
    A2AQD4, A5D8Z6, Q08E80, Q14BJ9, Q544I3, Q68FN1, Q75WU7, Q8CH96, Q8VEF7, Q922B9
    UniProtKB/TrEMBL
    A2AQD6
    Conserved Domains (2) summary
    pfam14722
    Location:146 → 297
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
    pfam14723
    Location:861 → 1029
    SSFA2_C; Sperm-specific antigen 2 C-terminus

  2. XM_036162565.1 → XP_036018458.1  protein ITPRID2 isoform X2

    UniProtKB/TrEMBL
    A2AQD5, A2AQD6
    Related
    ENSMUSP00000107414.3, ENSMUST00000111784.9
    Conserved Domains (2) summary
    pfam14722
    Location:146 → 297
    KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
    pfam14723
    Location:861 → 1029
    SSFA2_C; Sperm-specific antigen 2 C-terminus

  3. XM_006500165.4 → XP_006500228.1  protein ITPRID2 isoform X3

    Conserved Domains (1) summary
    pfam14723
    Location:373 → 539
    SSFA2_C; Sperm-specific antigen 2 C-terminus

RNA

  1. XR_001783177.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922B9.3 GenPept UniProtKB/Swiss-Prot:Q922B9

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