Gpr137c G protein-coupled receptor 137C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr137cprovided by MGI
Official Full Name: G protein-coupled receptor 137Cprovided by MGI
Primary source: MGI:MGI:1917963
See related: Ensembl:ENSMUSG00000049092 AllianceGenome:MGI:1917963
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm908; TM7SF1L2; 6330416L11Rik
Summary: Predicted to be involved in positive regulation of TORC1 signaling. Predicted to be located in lysosome and membrane. Predicted to be integral component of membrane. Predicted to be active in lysosomal membrane. Orthologous to human GPR137C (G protein-coupled receptor 137C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 4.5), whole brain E14.5 (RPKM 3.6) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 22.82 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (45457142..45520192)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (45219685..45282735)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G protein-coupled receptor 137C

Names: G protein-coupled receptor TM7SF1L2; integral membrane protein GPR137C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027518.2 → NP_081794.2 G protein-coupled receptor 137C

Status: VALIDATED

Source sequence(s)

AC154575

Consensus CDS

CCDS49464.1

UniProtKB/Swiss-Prot

E9Q343

Related

ENSMUSP00000120015.2, ENSMUST00000146150.3

Conserved Domains (2) summary

cd21464
Location:44 → 66

7tm_GPR137; TM helix 1 [structural motif]

cl28897
Location:36 → 357

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily