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Rasgef1a RasGEF domain family, member 1A [ Mus musculus (house mouse) ]

Gene ID: 70727, updated on 23-Jun-2021

Summary

Official Symbol
Rasgef1aprovided by MGI
Official Full Name
RasGEF domain family, member 1Aprovided by MGI
Primary source
MGI:MGI:1917977
See related
Ensembl:ENSMUSG00000030134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI835194; 6330404M18Rik
Expression
Biased expression in frontal lobe adult (RPKM 25.3), cortex adult (RPKM 24.6) and 3 other tissues See more
Orthologs
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Genomic context

See Rasgef1a in Genome Data Viewer
Location:
6; 6 F1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (117988466..118068507)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118011505..118091546)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (118016403..118041564)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene FXYD domain-containing ion transport regulator 4 Neighboring gene predicted gene, 38884 Neighboring gene Lasp1 pseudogene Neighboring gene microRNA 7044 Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 Neighboring gene predicted gene, 23908 Neighboring gene ret proto-oncogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
ras-GEF domain-containing family member 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316749.2NP_001303678.1  ras-GEF domain-containing family member 1A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 3. Variants 2 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC135861
    Consensus CDS
    CCDS85141.1
    UniProtKB/TrEMBL
    A6H650, Q3TYC0
    Related
    ENSMUSP00000132244.3, ENSMUST00000164960.4
    Conserved Domains (2) summary
    cd06224
    Location:49176
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    pfam00617
    Location:218410
    RasGEF; RasGEF domain
  2. NM_001362103.1NP_001349032.1  ras-GEF domain-containing family member 1A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC135861
    Consensus CDS
    CCDS90110.1
    Related
    ENSMUSP00000145214.2, ENSMUST00000203804.3
    Conserved Domains (2) summary
    cd06224
    Location:57163
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    pfam00617
    Location:235427
    RasGEF; RasGEF domain
  3. NM_001362104.1NP_001349033.1  ras-GEF domain-containing family member 1A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 3. Variants 2 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC135861
    Consensus CDS
    CCDS85141.1
    Conserved Domains (2) summary
    cd06224
    Location:49176
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    pfam00617
    Location:218410
    RasGEF; RasGEF domain
  4. NM_001362105.1NP_001349034.1  ras-GEF domain-containing family member 1A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (4) has a longer and distinct N-terminus and lacks an alternate internal segment compared to isoform 3.
    Source sequence(s)
    AC135861
    Conserved Domains (2) summary
    cd06224
    Location:60187
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    pfam00617
    Location:229421
    RasGEF; RasGEF domain
  5. NM_027526.1NP_081802.1  ras-GEF domain-containing family member 1A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.
    Source sequence(s)
    AK018120, AK158756, BY120855, BY256830
    Consensus CDS
    CCDS51883.1
    UniProtKB/TrEMBL
    A0A0N4SVF2, Q3TYC0
    Related
    ENSMUSP00000145077.2, ENSMUST00000203482.2
    Conserved Domains (2) summary
    cd06224
    Location:57184
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:222470
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    117988466..118068507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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