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Kynu kynureninase [ Mus musculus (house mouse) ]

Gene ID: 70789, updated on 23-Jun-2021

Summary

Official Symbol
Kynuprovided by MGI
Official Full Name
kynureninaseprovided by MGI
Primary source
MGI:MGI:1918039
See related
Ensembl:ENSMUSG00000026866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4432411A05Rik
Expression
Biased expression in liver adult (RPKM 9.9), liver E18 (RPKM 4.5) and 5 other tissues See more
Orthologs
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Genomic context

See Kynu in Genome Data Viewer
Location:
2; 2 B
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (43445270..43573060)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (43555258..43683048)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (43410849..43538235)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54112 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 30374 Neighboring gene Rho GTPase activating protein 15 Neighboring gene predicted gene, 39804

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-hydroxykynureninase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables kynureninase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kynureninase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in NAD biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in anthranilate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in anthranilate metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pyridine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in quinolinate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
involved_in response to vitamin B6 ISO
Inferred from Sequence Orthology
more info
 
involved_in tryptophan catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in tryptophan catabolic process to acetyl-CoA ISO
Inferred from Sequence Orthology
more info
 
involved_in tryptophan catabolic process to kynurenine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kynureninase
Names
L-kynurenine hydrolase
NP_001276522.1
NP_001276523.1
NP_081828.1
XP_006498388.1
XP_011237480.1
XP_011237481.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289593.1NP_001276522.1  kynureninase isoform 2

    See identical proteins and their annotated locations for NP_001276522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a 3' terminal exon which extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK050024, AK149423, AL845160
    Consensus CDS
    CCDS79792.1
    UniProtKB/Swiss-Prot
    Q9CXF0
    UniProtKB/TrEMBL
    Q6NSV5
    Related
    ENSMUSP00000108445.2, ENSMUST00000112826.8
    Conserved Domains (2) summary
    TIGR01814
    Location:31426
    kynureninase; kynureninase
    cl18945
    Location:25426
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  2. NM_001289594.1NP_001276523.1  kynureninase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK050024, AK149423, AL845336
    Consensus CDS
    CCDS79791.1
    UniProtKB/Swiss-Prot
    Q9CXF0
    UniProtKB/TrEMBL
    A2ARD7
    Related
    ENSMUSP00000061775.7, ENSMUST00000050511.7
    Conserved Domains (1) summary
    cl18945
    Location:25303
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  3. NM_027552.2NP_081828.1  kynureninase isoform 1

    See identical proteins and their annotated locations for NP_081828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK014484, AK149423, AL845160
    Consensus CDS
    CCDS16018.1
    UniProtKB/Swiss-Prot
    Q9CXF0
    UniProtKB/TrEMBL
    A2ARD6
    Related
    ENSMUSP00000028223.3, ENSMUST00000028223.9
    Conserved Domains (1) summary
    TIGR01814
    Location:31460
    kynureninase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    43445270..43573060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498325.3XP_006498388.1  kynureninase isoform X1

    See identical proteins and their annotated locations for XP_006498388.1

    UniProtKB/Swiss-Prot
    Q9CXF0
    UniProtKB/TrEMBL
    A2ARD6
    Conserved Domains (1) summary
    TIGR01814
    Location:31460
    kynureninase
  2. XM_011239179.3XP_011237481.1  kynureninase isoform X3

    Conserved Domains (1) summary
    TIGR01814
    Location:31427
    kynureninase
  3. XM_011239178.1XP_011237480.1  kynureninase isoform X2

    Conserved Domains (1) summary
    TIGR01814
    Location:31436
    kynureninase
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