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Hars2 histidyl-tRNA synthetase 2 [ Mus musculus (house mouse) ]

Gene ID: 70791, updated on 5-Mar-2024

Summary

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Official Symbol
Hars2provided by MGI
Official Full Name
histidyl-tRNA synthetase 2provided by MGI
Primary source
MGI:MGI:1918041
See related
Ensembl:ENSMUSG00000019143 AllianceGenome:MGI:1918041
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HO3; HARSR; Harsl; 4631412B19Rik
Summary
This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of histidine to tRNA molecules. Mutations in a similar gene in human have been associated with Perrault syndrome 2 (PRLTS2). [provided by RefSeq, Mar 2015]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.8), CNS E14 (RPKM 10.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B2; 18 19.46 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36916257..36925615)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36783202..36792562)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E617 Neighboring gene IK cytokine Neighboring gene WD repeat domain 55 Neighboring gene DND microRNA-mediated repression inhibitor 1 Neighboring gene histidyl-tRNA synthetase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8710 Neighboring gene STARR-positive B cell enhancer ABC_E3227 Neighboring gene zinc finger, matrin type 2 Neighboring gene STARR-positive B cell enhancer ABC_E1207 Neighboring gene vault RNA component 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of Hars2 in Cochlear Hair Cells Causes Progressive Mitochondrial Dysfunction and Hearing Loss in Mice. Xu P, et al. Front Cell Neurosci, 2021. PMID 34975414, Free PMC Article
  2. Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome. Pierce SB, et al. Proc Natl Acad Sci U S A, 2011 Apr 19. PMID 21464306, Free PMC Article
  3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables histidine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histidine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in histidyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in histidyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histidine--tRNA ligase, mitochondrial
Names
hisRS
histidyl-tRNA synthetase 2, mitochondrial (putative)
probable histidine--tRNA ligase, mitochondrial
probable histidyl-tRNA synthetase, mitochondrial
NP_001292556.1
NP_001347850.1
NP_542367.1
XP_011245301.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305627.1 → NP_001292556.1  histidine--tRNA ligase, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_001292556.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC027740, AI593507, AK077621
    Consensus CDS
    CCDS84376.1
    UniProtKB/TrEMBL
    G5E823
    Related
    ENSMUSP00000019287.9, ENSMUST00000019287.9
    Conserved Domains (3) summary
    COG0124
    Location:56 → 422
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cd00773
    Location:69 → 243
    HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00859
    Location:327 → 418
    HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

  2. NM_001360921.1 → NP_001347850.1  histidine--tRNA ligase, mitochondrial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the coding region, lacks an exon in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC027740
    Conserved Domains (1) summary
    cl28413
    Location:2 → 330
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  3. NM_080636.2 → NP_542367.1  histidine--tRNA ligase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_542367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC027740, AI593507, AK077621
    Consensus CDS
    CCDS29165.1
    UniProtKB/Swiss-Prot
    Q99KK9
    Related
    ENSMUSP00000117231.2, ENSMUST00000152954.8
    Conserved Domains (3) summary
    COG0124
    Location:56 → 503
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cd00773
    Location:69 → 394
    HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00859
    Location:408 → 499
    HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36916257..36925615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246999.3 → XP_011245301.1  histidine--tRNA ligase, mitochondrial isoform X1

    Conserved Domains (1) summary
    PLN02972
    Location:1 → 363
    PLN02972; Histidyl-tRNA synthetase

RNA

  1. XR_386015.4 RNA Sequence

  2. XR_003952541.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KK9.1 GenPept UniProtKB/Swiss-Prot:Q99KK9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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