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Cnbd2 cyclic nucleotide binding domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 70873, updated on 5-Mar-2024

Summary

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Official Symbol
Cnbd2provided by MGI
Official Full Name
cyclic nucleotide binding domain containing 2provided by MGI
Primary source
MGI:MGI:1918123
See related
Ensembl:ENSMUSG00000038085 AllianceGenome:MGI:1918123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cris; 4921517L17Rik; 5430421B09Rik
Summary
Enables cAMP binding activity. Acts upstream of or within spermatogenesis. Located in cytosol. Orthologous to human CNBD2 (cyclic nucleotide binding domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 14.9), spleen adult (RPKM 5.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 77.39 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156153866..156217558)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156311946..156375638)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 39 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156005117-156005304 Neighboring gene STARR-positive B cell enhancer ABC_E817 Neighboring gene STARR-seq mESC enhancer starr_06156 Neighboring gene STARR-positive B cell enhancer ABC_E9537 Neighboring gene STARR-seq mESC enhancer starr_06157 Neighboring gene PHD finger protein 20 Neighboring gene STARR-seq mESC enhancer starr_06159 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156104477-156104678 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156113998-156114107 Neighboring gene SCAN domain-containing 1 Neighboring gene predicted gene 14251 Neighboring gene STARR-seq mESC enhancer starr_06163 Neighboring gene STARR-positive B cell enhancer mm9_chr2:156182424-156182725 Neighboring gene programmed cell death 10 pseudogene Neighboring gene predicted gene 14170 Neighboring gene ribosomal protein L21, pseudogene 9 Neighboring gene non-coding RNA activated by DNA damage

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending. Krähling AM, et al. PLoS Genet, 2013. PMID 24339785, Free PMC Article
  2. Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Tkatchenko TV, et al. Physiol Genomics, 2009 Nov 6. PMID 19723774, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclic nucleotide-binding domain-containing protein 2
Names
cyclic nucleotide-receptor involved in sperm function

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316755.1 → NP_001303684.1  cyclic nucleotide-binding domain-containing protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 3' exon in place of the last four exons compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK162372, BY097898
    UniProtKB/TrEMBL
    Q3TRZ7
    Conserved Domains (2) summary
    COG0664
    Location:200 → 353
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:200 → 308
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  2. NM_027585.2 → NP_081861.2  cyclic nucleotide-binding domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_081861.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK014912, BX637137, BY097898
    Consensus CDS
    CCDS50778.1
    UniProtKB/Swiss-Prot
    A2ATV2, Q8R083, Q9D5U8
    UniProtKB/TrEMBL
    B2RU56, S4S403
    Related
    ENSMUSP00000041268.3, ENSMUST00000037096.9
    Conserved Domains (2) summary
    COG0664
    Location:200 → 353
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:211 → 308
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    156153866..156217558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252071.2 → XP_030107931.1  cyclic nucleotide-binding domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    Q3TRZ7
    Conserved Domains (1) summary
    cd00038
    Location:165 → 262
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  2. XM_036162566.1 → XP_036018459.1  cyclic nucleotide-binding domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    B2RU56, S4S403
    Conserved Domains (1) summary
    cd00038
    Location:200 → 308
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  3. XM_006500172.5 → XP_006500235.1  cyclic nucleotide-binding domain-containing protein 2 isoform X5

    Conserved Domains (1) summary
    cd00038
    Location:211 → 308
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  4. XM_006500167.4 → XP_006500230.1  cyclic nucleotide-binding domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    B2RU56, S4S403
    Conserved Domains (1) summary
    cd00038
    Location:165 → 262
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  5. XM_036162567.1 → XP_036018460.1  cyclic nucleotide-binding domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    cd00038
    Location:154 → 262
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RNA

  1. XR_003953718.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D5U8.2 GenPept UniProtKB/Swiss-Prot:Q9D5U8

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