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Wdr31 WD repeat domain 31 [ Mus musculus (house mouse) ]

Gene ID: 71354, updated on 5-Mar-2024

Summary

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Official Symbol
Wdr31provided by MGI
Official Full Name
WD repeat domain 31provided by MGI
Primary source
MGI:MGI:1918604
See related
Ensembl:ENSMUSG00000028391 AllianceGenome:MGI:1918604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
spWD; 5430402I10Rik
Summary
Is expressed in several structures, including alimentary system; brain ventricle and choroid plexus; genitourinary system; lung; and olfactory epithelium. Orthologous to human WDR31 (WD repeat domain 31). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 27.3), kidney adult (RPKM 1.6) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
4 B3; 4 33.14 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62366890..62389236, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62448653..62470999, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:62069546-62069847 Neighboring gene pre-mRNA processing factor 4 Neighboring gene ring finger protein 183 Neighboring gene predicted gene, 30589 Neighboring gene B-box and SPRY domain containing Neighboring gene haloacid dehalogenase-like hydrolase domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential display to identify and isolate novel genes expressed during spermatogenesis. Catalano RD, et al. Mol Hum Reprod, 1997 Mar. PMID 9237247
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 31
Names
spermatid WD repeat-containing protein
spermatid WD-repeat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290521.2 → NP_001277450.1  WD repeat-containing protein 31 isoform 1

    See identical proteins and their annotated locations for NP_001277450.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK141026, AL732594, CK618879
    Consensus CDS
    CCDS18240.1
    UniProtKB/Swiss-Prot
    Q3URZ0, Q9D3N4, Q9JHB4
    Related
    ENSMUSP00000112719.2, ENSMUST00000120095.8
    Conserved Domains (2) summary
    cd00200
    Location:61 → 344
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:65 → 101
    7WD40; WD40 repeat [structural motif]

  2. NM_001290522.2 → NP_001277451.1  WD repeat-containing protein 31 isoform 2

    See identical proteins and their annotated locations for NP_001277451.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
    Source sequence(s)
    AK017259, AK141026, AL732594, CK618879
    Consensus CDS
    CCDS71402.1
    UniProtKB/Swiss-Prot
    Q9JHB4
    Related
    ENSMUSP00000103076.2, ENSMUST00000107452.8
    Conserved Domains (3) summary
    COG2319
    Location:60 → 342
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:60 → 343
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:64 → 100
    7WD40; WD40 repeat [structural motif]

  3. NM_001355523.1 → NP_001342452.1  WD repeat-containing protein 31 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region, compared to variant 1, which results in a translational framshift It encodes isoform 3 which has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK017259, AK141026, AL732594, AV039764, CK618879
    Conserved Domains (2) summary
    sd00039
    Location:66 → 101
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:61 → 250
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_023597.3 → NP_076086.1  WD repeat-containing protein 31 isoform 1

    See identical proteins and their annotated locations for NP_076086.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK017259, AK141026, AL732594, CK618879
    Consensus CDS
    CCDS18240.1
    UniProtKB/Swiss-Prot
    Q3URZ0, Q9D3N4, Q9JHB4
    Related
    ENSMUSP00000030087.8, ENSMUST00000030087.14
    Conserved Domains (2) summary
    cd00200
    Location:61 → 344
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:65 → 101
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    62366890..62389236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538257.4 → XP_006538320.1  WD repeat-containing protein 31 isoform X2

    Related
    ENSMUST00000146108.8
    Conserved Domains (2) summary
    cd00200
    Location:61 → 316
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:65 → 101
    7WD40; WD40 repeat [structural motif]

  2. XM_006538259.4 → XP_006538322.1  WD repeat-containing protein 31 isoform X4

    See identical proteins and their annotated locations for XP_006538322.1

    Conserved Domains (2) summary
    sd00039
    Location:66 → 101
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:61 → 250
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_006538258.4 → XP_006538321.1  WD repeat-containing protein 31 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:66 → 101
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:61 → 215
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_036164428.1 → XP_036020321.1  WD repeat-containing protein 31 isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:66 → 101
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:61 → 215
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_030253780.2 → XP_030109640.1  WD repeat-containing protein 31 isoform X5

    Conserved Domains (2) summary
    sd00039
    Location:65 → 100
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:60 → 249
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_006538254.3 → XP_006538317.1  WD repeat-containing protein 31 isoform X1

    See identical proteins and their annotated locations for XP_006538317.1

    UniProtKB/Swiss-Prot
    Q3URZ0, Q9D3N4, Q9JHB4
    Conserved Domains (2) summary
    cd00200
    Location:61 → 344
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:65 → 101
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_004941962.1 RNA Sequence

  2. XR_390342.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHB4.1 GenPept UniProtKB/Swiss-Prot:Q9JHB4

Gene LinkOut

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