Mettl13 methyltransferase 13, eEF1A lysine and N-terminal methyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mettl13provided by MGI
Official Full Name: methyltransferase 13, eEF1A lysine and N-terminal methyltransferaseprovided by MGI
Primary source: MGI:MGI:1918699
See related: Ensembl:ENSMUSG00000026694 AllianceGenome:MGI:1918699
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eef1aknmt; 5630401D24Rik
Summary: Predicted to enable methyltransferase activity. Predicted to be involved in negative regulation of cell cycle G1/S phase transition and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within methylation. Located in mitochondrion and nucleus. Is expressed in axial musculature and submandibular gland primordium. Orthologous to human METTL13 (methyltransferase 13, eEF1A lysine and N-terminal methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 6.1), limb E14.5 (RPKM 5.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.1; 1 70.29 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (162359694..162376098, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (162533671..162548541, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure.
Title: Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure.
Results suggest that FEAT facilitates the INSL3 production in testicular Leydig cells that is essential for transabdominal testis migration.
Title: FEAT enhances INSL3 expression in testicular Leydig cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eEF1A lysine and N-terminal methyltransferase

Names: EEF1A lysine and N-terminal methyltransferase; eEF1A-KNMT; methyltransferase like 13; methyltransferase-like protein 13

NP_001404810.1

EC 2.1.1.-

NP_001404811.1

EC 2.1.1.-

NP_659126.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417881.1 → NP_001404810.1 eEF1A lysine and N-terminal methyltransferase isoform 2

Status: VALIDATED

Source sequence(s)

AC138218
NM_001417882.1 → NP_001404811.1 eEF1A lysine and N-terminal methyltransferase isoform 3

Status: VALIDATED

Source sequence(s)

AC138218
NM_144877.2 → NP_659126.1 eEF1A lysine and N-terminal methyltransferase isoform 1

See identical proteins and their annotated locations for NP_659126.1

Status: VALIDATED

Source sequence(s)

AC138218

Consensus CDS

CCDS15420.1

UniProtKB/Swiss-Prot

Q3TF24, Q3TFY3, Q69ZX4, Q8BWN2, Q8BX81, Q91YR5

Related

ENSMUSP00000028017.9, ENSMUST00000028017.16

Conserved Domains (3) summary

COG0500
Location:501 → 649

SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

pfam08241
Location:53 → 158

Methyltransf_11; Methyltransferase domain

cl17173
Location:500 → 672

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...