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Afmid arylformamidase [ Mus musculus (house mouse) ]

Gene ID: 71562, updated on 5-Mar-2024

Summary

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Official Symbol
Afmidprovided by MGI
Official Full Name
arylformamidaseprovided by MGI
Primary source
MGI:MGI:2448704
See related
Ensembl:ENSMUSG00000017718 AllianceGenome:MGI:2448704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kf; FKF; KFA; Ammd; formylase; 9030621K19Rik
Summary
Predicted to enable hydrolase activity. Acts upstream of or within tryptophan catabolic process to kynurenine. Located in cytoplasm. Is expressed in genitourinary system; nervous system; parathyroid gland; and respiratory system. Orthologous to human AFMID (arylformamidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 32.0), kidney adult (RPKM 20.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 82.96 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117716329..117730734)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117825503..117839908)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6030468B19 gene Neighboring gene STARR-positive B cell enhancer ABC_E5305 Neighboring gene STARR-positive B cell enhancer ABC_E5306 Neighboring gene synaptogyrin 2 Neighboring gene thymidine kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E11501 Neighboring gene STARR-positive B cell enhancer ABC_E4020 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117693509-117693710 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117693767-117693876 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117710178-117710379 Neighboring gene baculoviral IAP repeat-containing 5 Neighboring gene VISTA enhancer mm780 Neighboring gene transmembrane protein 235

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance. Hugill AJ, et al. Biol Open, 2015 Oct 2. PMID 26432886, Free PMC Article
  2. Cloning, expression, and catalytic triad of recombinant arylformamidase. Pabarcus MK, et al. Protein Expr Purif, 2005 Nov. PMID 15935693
  3. Comprehensive analysis of the mouse metabolome based on the transcriptome. Bono H, et al. Genome Res, 2003 Jun. PMID 12819132, Free PMC Article
  4. Kynurenine formamidase: determination of primary structure and modeling-based prediction of tertiary structure and catalytic triad. Pabarcus MK, et al. Biochim Biophys Acta, 2002 Apr 29. PMID 12007602
  5. Monitoring type 2 diabetes from volatile faecal metabolome in Cushing's syndrome and single Afmid mouse models via a longitudinal study. Lourenço C, et al. Sci Rep, 2019 Dec 11. PMID 31827172, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Monitoring type 2 diabetes from volatile faecal metabolome in Cushing's syndrome and single Afmid mouse models via a longitudinal study.
    Title: Monitoring type 2 diabetes from volatile faecal metabolome in Cushing's syndrome and single Afmid mouse models via a longitudinal study.
  2. Arylformamidase function is in eliminating toxic metabolites and to a lesser extent in providing intermediates for other processes.
    Title: Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype.
  3. activation from a bidirectional promoter is linked to changes in histone modification
    Title: Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arylformamidase activity IEA
Inferred from Electronic Annotation
more info
  
enables arylformamidase activity TAS
Traceable Author Statement
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within tryptophan catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan catabolic process to kynurenine IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tryptophan catabolic process to kynurenine IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kynurenine formamidase
Names
KFase
N-formylkynurenine formamidase
formylkynureninase
probable arylformamidase
NP_001350087.1
NP_001350088.1
NP_001350089.1
NP_082103.1
XP_006534310.1
XP_006534311.1
XP_006534312.1
XP_006534313.1
XP_011247570.1
XP_030102185.1
XP_030102186.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363158.1 → NP_001350087.1  kynurenine formamidase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591433
    UniProtKB/TrEMBL
    B1AQL0
    Related
    ENSMUST00000148016.8
    Conserved Domains (1) summary
    COG0657
    Location:5 → 285
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

  2. NM_001363159.1 → NP_001350088.1  kynurenine formamidase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591433
    UniProtKB/TrEMBL
    B1AQL0
    Related
    ENSMUSP00000119310.2, ENSMUST00000149668.2
    Conserved Domains (1) summary
    COG0657
    Location:55 → 279
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

  3. NM_001363160.1 → NP_001350089.1  kynurenine formamidase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591433
    Conserved Domains (1) summary
    COG0657
    Location:55 → 260
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

  4. NM_027827.3 → NP_082103.1  kynurenine formamidase isoform 3

    See identical proteins and their annotated locations for NP_082103.1

    Status: VALIDATED

    Source sequence(s)
    AL591433, AY099479, BY780917
    Consensus CDS
    CCDS25693.1
    UniProtKB/Swiss-Prot
    B1AQK9, Q80XP3, Q8K4H1, Q8R1K6
    Related
    ENSMUSP00000073102.7, ENSMUST00000073388.13
    Conserved Domains (2) summary
    pfam12697
    Location:89 → 280
    Abhydrolase_6; Alpha/beta hydrolase family
    cl21494
    Location:89 → 279
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    117716329..117730734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246326.1 → XP_030102186.1  kynurenine formamidase isoform X6

    Conserved Domains (1) summary
    COG0657
    Location:70 → 220
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

  2. XM_006534248.2 → XP_006534311.1  kynurenine formamidase isoform X2

    Conserved Domains (1) summary
    COG0657
    Location:55 → 262
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

  3. XM_006534249.2 → XP_006534312.1  kynurenine formamidase isoform X4

    Conserved Domains (1) summary
    COG0657
    Location:70 → 203
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

  4. XM_006534247.4 → XP_006534310.1  kynurenine formamidase isoform X1

    Conserved Domains (1) summary
    COG0657
    Location:5 → 268
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

  5. XM_030246325.2 → XP_030102185.1  kynurenine formamidase isoform X3

    Conserved Domains (1) summary
    COG0657
    Location:5 → 285
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

  6. XM_006534250.4 → XP_006534313.1  kynurenine formamidase isoform X5

    Conserved Domains (1) summary
    COG0657
    Location:66 → 199
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

  7. XM_011249268.3 → XP_011247570.1  kynurenine formamidase isoform X7

    Conserved Domains (1) summary
    COG0657
    Location:5 → 192
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

RNA

  1. XR_004937035.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4H1.1 GenPept UniProtKB/Swiss-Prot:Q8K4H1

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