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SETDB1 SET domain bifurcated histone lysine methyltransferase 1 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 716141, updated on 5-Mar-2024

Summary

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Official Symbol
SETDB1provided by VGNC
Official Full Name
SET domain bifurcated histone lysine methyltransferase 1provided by VGNC
Primary source
VGNC:VGNC:100139
See related
Ensembl:ENSMMUG00000023235
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See SETDB1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
23
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (100163778..100205148, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (125388920..125431903)

Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene annexin A9 Neighboring gene ceramide synthase 2 Neighboring gene cytochrome c-like Neighboring gene aryl hydrocarbon receptor nuclear translocator Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone H3K9 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterochromatin organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase SETDB1
Names
SET domain bifurcated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041754.1 Reference Mmul_10 Primary Assembly

    Range
    100163778..100205148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028829244.1 → XP_028685077.1  histone-lysine N-methyltransferase SETDB1 isoform X2

    UniProtKB/TrEMBL
    G7MDI5
    Conserved Domains (4) summary
    smart00391
    Location:634 → 709
    MBD; Methyl-CpG binding domain
    smart00333
    Location:385 → 437
    TUDOR; Tudor domain
    smart00317
    Location:1243 → 1305
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam05033
    Location:719 → 832
    Pre-SET; Pre-SET motif

  2. XM_028829243.1 → XP_028685076.1  histone-lysine N-methyltransferase SETDB1 isoform X1

    UniProtKB/TrEMBL
    G7MDI5
    Conserved Domains (4) summary
    smart00391
    Location:635 → 710
    MBD; Methyl-CpG binding domain
    smart00333
    Location:385 → 437
    TUDOR; Tudor domain
    smart00317
    Location:1244 → 1306
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam05033
    Location:720 → 833
    Pre-SET; Pre-SET motif

  3. XM_015151793.1 → XP_015007279.1  histone-lysine N-methyltransferase SETDB1 isoform X4

    UniProtKB/TrEMBL
    G7MDI5
    Conserved Domains (4) summary
    smart00391
    Location:597 → 672
    MBD; Methyl-CpG binding domain
    smart00468
    Location:679 → 786
    PreSET; N-terminal to some SET domains
    smart00333
    Location:348 → 400
    TUDOR; Tudor domain
    smart00317
    Location:1206 → 1268
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

  4. XM_028829249.1 → XP_028685082.1  histone-lysine N-methyltransferase SETDB1 isoform X3

    UniProtKB/TrEMBL
    F7BT27, G7MDI5, H9G2L0
    Related
    ENSMMUP00000039118.2, ENSMMUT00000046077.3
    Conserved Domains (4) summary
    smart00391
    Location:598 → 673
    MBD; Methyl-CpG binding domain
    smart00468
    Location:680 → 787
    PreSET; N-terminal to some SET domains
    smart00333
    Location:348 → 400
    TUDOR; Tudor domain
    smart00317
    Location:1207 → 1269
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

  5. XM_028829253.1 → XP_028685086.1  histone-lysine N-methyltransferase SETDB1 isoform X5

    Conserved Domains (3) summary
    pfam18300
    Location:193 → 250
    DUF5604; Domain of unknown function (DUF5604)
    pfam18358
    Location:348 → 380
    Tudor_4; Histone methyltransferase Tudor domain
    cd20382
    Location:260 → 341
    Tudor_SETDB1_rpt1; first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins
Nucleotide Protein
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