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Zfp949 zinc finger protein 949 [ Mus musculus (house mouse) ]

Gene ID: 71640, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp949provided by MGI
Official Full Name
zinc finger protein 949provided by MGI
Primary source
MGI:MGI:1918890
See related
Ensembl:ENSMUSG00000032425 AllianceGenome:MGI:1918890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nczf; 4930422I07Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 4.6), frontal lobe adult (RPKM 3.8) and 28 other tissues See more
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Genomic context

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Location:
9 E3.1; 9 47.24 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (88430073..88453139)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (88548020..88571086)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E251 Neighboring gene small nucleolar RNA, C/D box 50B Neighboring gene small nucleolar RNA host gene 5 Neighboring gene predicted gene, 22985 Neighboring gene STARR-positive B cell enhancer ABC_E6783 Neighboring gene STARR-positive B cell enhancer ABC_E8859 Neighboring gene tripartite motif-containing 43A Neighboring gene predicted gene, 51715 Neighboring gene RIKEN cDNA 9430037G07 gene Neighboring gene transcription elongation factor B polypeptide 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of the consensus DNA sequence for Nczf binding. Kitahashi M, et al. DNA Cell Biol, 2007 Jun. PMID 17570763
  2. Transcriptional repression of p27 is essential for murine embryonic development. Teratake Y, et al. Sci Rep, 2016 May 19. PMID 27196371, Free PMC Article
  3. Candidate genes and their regulatory elements: alcohol preference and tolerance. Saba L, et al. Mamm Genome, 2006 Jun. PMID 16783646
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC71640

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142943.1 → NP_001136415.1  uncharacterized protein LOC71640

    See identical proteins and their annotated locations for NP_001136415.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC163666, AK015179, BC141010, BU610496
    Consensus CDS
    CCDS52880.1
    UniProtKB/TrEMBL
    E9Q732
    Related
    ENSMUSP00000125325.2, ENSMUST00000162827.8
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:246 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:438 → 458
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001163061.1 → NP_001156533.1  uncharacterized protein LOC71640

    See identical proteins and their annotated locations for NP_001156533.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC163666, CT025673
    Consensus CDS
    CCDS52880.1
    UniProtKB/TrEMBL
    E9Q732
    Related
    ENSMUSP00000125017.2, ENSMUST00000161458.3
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:246 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:438 → 458
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    88430073..88453139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244606.1 → XP_030100466.1  uncharacterized protein LOC71640 isoform X1

    UniProtKB/TrEMBL
    E9Q732
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:246 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:438 → 458
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_036155290.1 → XP_036011183.1  uncharacterized protein LOC71640 isoform X1

    UniProtKB/TrEMBL
    E9Q732
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:246 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:438 → 458
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_030244605.1 → XP_030100465.1  uncharacterized protein LOC71640 isoform X1

    UniProtKB/TrEMBL
    E9Q732
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:246 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:438 → 458
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_017313596.2 → XP_017169085.1  uncharacterized protein LOC71640 isoform X1

    UniProtKB/TrEMBL
    E9Q732
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:246 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:438 → 458
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_036155291.1 → XP_036011184.1  uncharacterized protein LOC71640 isoform X1

    UniProtKB/TrEMBL
    E9Q732
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:246 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:438 → 458
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_006511446.5 → XP_006511509.1  uncharacterized protein LOC71640 isoform X1

    See identical proteins and their annotated locations for XP_006511509.1

    UniProtKB/TrEMBL
    E9Q732
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:246 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:438 → 458
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_030244604.2 → XP_030100464.1  uncharacterized protein LOC71640 isoform X1

    UniProtKB/TrEMBL
    E9Q732
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:246 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:438 → 458
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_030244607.2 → XP_030100467.1  uncharacterized protein LOC71640 isoform X1

    UniProtKB/TrEMBL
    E9Q732
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:246 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:438 → 458
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. XM_030244608.2 → XP_030100468.1  uncharacterized protein LOC71640 isoform X2

    Conserved Domains (3) summary
    smart00349
    Location:2 → 38
    KRAB; krueppel associated box
    COG5048
    Location:216 → 564
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:408 → 428
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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