U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tmem25 transmembrane protein 25 [ Mus musculus (house mouse) ]

Gene ID: 71687, updated on 5-Mar-2024

Summary

Official Symbol
Tmem25provided by MGI
Official Full Name
transmembrane protein 25provided by MGI
Primary source
MGI:MGI:1918937
See related
Ensembl:ENSMUSG00000002032 AllianceGenome:MGI:1918937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610039J01Rik
Summary
Involved in negative regulation of excitatory postsynaptic potential and regulation of protein stability. Located in late endosome and lysosome. Is expressed in basioccipital bone; orbito-sphenoid; and temporal bone petrous part. Orthologous to human TMEM25 (transmembrane protein 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 44.3), liver adult (RPKM 27.1) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
9 A5.2; 9 24.84 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44705069..44710821, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44793772..44799524, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene archain 1 Neighboring gene STARR-positive B cell enhancer ABC_E9756 Neighboring gene intraflagellar transport 46 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene lysine (K)-specific methyltransferase 2A Neighboring gene predicted gene, 39326 Neighboring gene STARR-positive B cell enhancer ABC_E6728 Neighboring gene STARR-seq mESC enhancer starr_23986 Neighboring gene predicted gene, 30883

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357383.1NP_001344312.1  transmembrane protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC142113
    UniProtKB/TrEMBL
    Q3U4J4
    Conserved Domains (1) summary
    cl11960
    Location:51142
    Ig; Immunoglobulin domain
  2. NM_001357384.1NP_001344313.1  transmembrane protein 25 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC142113
    Consensus CDS
    CCDS23120.1
    UniProtKB/Swiss-Prot
    Q3TMP3, Q6PAK7, Q9DCF1
    UniProtKB/TrEMBL
    Q3U4J4
    Conserved Domains (2) summary
    cd00096
    Location:3034
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
  3. NM_001357385.1NP_001344314.1  transmembrane protein 25 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC142113
    Consensus CDS
    CCDS23120.1
    UniProtKB/Swiss-Prot
    Q3TMP3, Q6PAK7, Q9DCF1
    UniProtKB/TrEMBL
    Q3U4J4
    Conserved Domains (2) summary
    cd00096
    Location:3034
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
  4. NM_001357386.1NP_001344315.1  transmembrane protein 25 isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AC142113, AK090375, AW457301
    Consensus CDS
    CCDS90554.1
    UniProtKB/TrEMBL
    A0A1N9MYB8
    Related
    ENSMUSP00000110353.3, ENSMUST00000114705.9
    Conserved Domains (2) summary
    cd00096
    Location:3034
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
  5. NM_027865.3NP_082141.1  transmembrane protein 25 isoform b precursor

    See identical proteins and their annotated locations for NP_082141.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AK165199, AW457301
    Consensus CDS
    CCDS23120.1
    UniProtKB/Swiss-Prot
    Q3TMP3, Q6PAK7, Q9DCF1
    UniProtKB/TrEMBL
    Q3U4J4
    Related
    ENSMUSP00000002100.8, ENSMUST00000002100.8
    Conserved Domains (2) summary
    cd00096
    Location:3034
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:27118
    Ig; Immunoglobulin domain

RNA

  1. NR_151678.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' end and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC142113
  2. NR_151679.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' end and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC142113
    Related
    ENSMUST00000132020.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44705069..44710821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244613.1XP_030100473.1  transmembrane protein 25 isoform X4

    UniProtKB/TrEMBL
    Q3U4J4
    Conserved Domains (1) summary
    cl11960
    Location:52143
    Ig; Immunoglobulin domain
  2. XM_030244612.1XP_030100472.1  transmembrane protein 25 isoform X3

    Conserved Domains (1) summary
    cl11960
    Location:127218
    Ig; Immunoglobulin domain
  3. XM_030244611.1XP_030100471.1  transmembrane protein 25 isoform X2

    Conserved Domains (1) summary
    cl11960
    Location:128219
    Ig; Immunoglobulin domain
  4. XM_030244609.1XP_030100469.1  transmembrane protein 25 isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:128219
    Ig; Immunoglobulin domain
  5. XM_030244614.2XP_030100474.1  transmembrane protein 25 isoform X7

    Conserved Domains (1) summary
    cl11960
    Location:51142
    Ig; Immunoglobulin domain
  6. XM_036155294.1XP_036011187.1  transmembrane protein 25 isoform X9

  7. XM_036155292.1XP_036011185.1  transmembrane protein 25 isoform X6

    Conserved Domains (2) summary
    cd00096
    Location:5559
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:52143
    Ig; Immunoglobulin domain
  8. XM_011242601.3XP_011240903.1  transmembrane protein 25 isoform X9

    See identical proteins and their annotated locations for XP_011240903.1

  9. XM_030244615.2XP_030100475.1  transmembrane protein 25 isoform X9

  10. XM_036155293.1XP_036011186.1  transmembrane protein 25 isoform X8

    UniProtKB/TrEMBL
    A0A1N9MYB8
    Conserved Domains (2) summary
    cd00096
    Location:3034
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
  11. XM_006510610.4XP_006510673.1  transmembrane protein 25 isoform X5

    See identical proteins and their annotated locations for XP_006510673.1

    UniProtKB/Swiss-Prot
    Q3TMP3, Q6PAK7, Q9DCF1
    UniProtKB/TrEMBL
    Q3U4J4
    Conserved Domains (2) summary
    cd00096
    Location:3034
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
  12. XM_036155295.1XP_036011188.1  transmembrane protein 25 isoform X9

  13. XM_011242602.1XP_011240904.1  transmembrane protein 25 isoform X9

    See identical proteins and their annotated locations for XP_011240904.1

  14. XM_030244616.1XP_030100476.1  transmembrane protein 25 isoform X9

  15. XM_011242603.2XP_011240905.1  transmembrane protein 25 isoform X9

    See identical proteins and their annotated locations for XP_011240905.1