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Syde1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) [ Mus musculus (house mouse) ]

Gene ID: 71709, updated on 5-Jan-2022

Summary

Official Symbol
Syde1provided by MGI
Official Full Name
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)provided by MGI
Primary source
MGI:MGI:1918959
See related
Ensembl:ENSMUSG00000032714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mSYD1A; BB043000; 1200008N06Rik
Summary
Enables GTPase activator activity. Acts upstream of or within several processes, including labyrinthine layer blood vessel development; synaptic vesicle docking; and synaptonemal complex assembly. Located in cerebellar mossy fiber; cytosol; and synaptic membrane. Is expressed in labyrinthine zone; placenta; spongiotrophoblast; trophectoderm; and trophoblast giant cell. Orthologous to human SYDE1 (synapse defective Rho GTPase homolog 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in lung adult (RPKM 28.5), adrenal adult (RPKM 26.5) and 24 other tissues See more
Orthologs
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Genomic context

See Syde1 in Genome Data Viewer
Location:
10; 10 C1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (78420336..78427798, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78584502..78591964, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (78047248..78054709, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor, pseudogene 92 Neighboring gene ilvB (bacterial acetolactate synthase)-like Neighboring gene predicted gene, 30346 Neighboring gene olfactory receptor 1357

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables GTPase regulator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cerebellar mossy fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rho GTPase-activating protein SYDE1
Names
protein syd-1 homolog 1
synapse defective protein 1 homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027875.1NP_082151.1  rho GTPase-activating protein SYDE1

    See identical proteins and their annotated locations for NP_082151.1

    Status: VALIDATED

    Source sequence(s)
    AC153887
    Consensus CDS
    CCDS48613.1
    UniProtKB/TrEMBL
    G3X960
    Related
    ENSMUSP00000043085.7, ENSMUST00000040580.7
    Conserved Domains (2) summary
    pfam16885
    Location:73250
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    cl02570
    Location:396601
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    78420336..78427798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514148.1XP_006514211.1  rho GTPase-activating protein SYDE1 isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:57263
    PHA03247; large tegument protein UL36; Provisional
    cl02570
    Location:396529
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

RNA

  1. XR_001779604.2 RNA Sequence

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