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Nectin4 nectin cell adhesion molecule 4 [ Mus musculus (house mouse) ]

Gene ID: 71740, updated on 5-Jan-2022

Summary

Official Symbol
Nectin4provided by MGI
Official Full Name
nectin cell adhesion molecule 4provided by MGI
Primary source
MGI:MGI:1918990
See related
Ensembl:ENSMUSG00000006411
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prr4; Pvrl4; 1200017F15Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to act upstream of or within cell-cell adhesion. Predicted to be located in plasma membrane. Predicted to be active in adherens junction. Is expressed in several structures, including alimentary system; genitourinary system; nose; respiratory system; and skin. Orthologous to human NECTIN4 (nectin cell adhesion molecule 4). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in bladder adult (RPKM 13.9), genital fat pad adult (RPKM 9.3) and 15 other tissues See more
Orthologs
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Genomic context

See Nectin4 in Genome Data Viewer
Location:
1; 1 H3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171197741..171215855)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171370173..171388287)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (173300304..173318418)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene death effector domain-containing Neighboring gene nitrilase 1 Neighboring gene prefoldin 2 Neighboring gene kelch domain containing 9 Neighboring gene Rho GTPase activating protein 30 Neighboring gene upstream transcription factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nectin-4
Names
ig superfamily receptor LNIR
nectin 4
poliovirus receptor-related 4
poliovirus receptor-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122680.1NP_001116152.1  nectin-4 isoform b precursor

    See identical proteins and their annotated locations for NP_001116152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a.
    Source sequence(s)
    AK004821, AK028479, BX638135, BY154786
    Consensus CDS
    CCDS48442.1
    UniProtKB/Swiss-Prot
    Q8R007
    Related
    ENSMUSP00000091883.5, ENSMUST00000094325.5
    Conserved Domains (4) summary
    cd00096
    Location:265328
    Ig; Immunoglobulin domain
    cd07704
    Location:148241
    Ig2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins
    smart00410
    Location:258331
    IG_like; Immunoglobulin like
    cl11960
    Location:45145
    Ig; Immunoglobulin domain
  2. NM_027893.3NP_082169.2  nectin-4 isoform a precursor

    See identical proteins and their annotated locations for NP_082169.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
    Source sequence(s)
    AK004821, AK028479, BX638135, BY154786
    Consensus CDS
    CCDS15493.1
    UniProtKB/Swiss-Prot
    Q8R007
    Related
    ENSMUSP00000006578.4, ENSMUST00000006578.10
    Conserved Domains (4) summary
    cd00096
    Location:265328
    Ig; Immunoglobulin domain
    cd07704
    Location:148241
    Ig2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3), nectin-4 (poliovirus receptor related protein 4) and similar proteins
    smart00410
    Location:258331
    IG_like; Immunoglobulin like
    cl11960
    Location:45145
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171197741..171215855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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