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Ulk3 unc-51-like kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 71742, updated on 11-Apr-2024

Summary

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Official Symbol
Ulk3provided by MGI
Official Full Name
unc-51-like kinase 3provided by MGI
Primary source
MGI:MGI:1918992
See related
Ensembl:ENSMUSG00000032308 AllianceGenome:MGI:1918992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200015E14Rik
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including fibroblast activation; protein phosphorylation; and regulation of smoothened signaling pathway. Predicted to act upstream of or within autophagy and phosphorylation. Predicted to be active in autophagosome. Orthologous to human ULK3 (unc-51 like kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 7.2), spleen adult (RPKM 6.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ulk3 in Genome Data Viewer
Location:
9 B; 9 31.09 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57496423..57503516)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57589141..57596233)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 219, member B Neighboring gene mannose phosphate isomerase Neighboring gene STARR-positive B cell enhancer ABC_E3834 Neighboring gene STARR-positive B cell enhancer ABC_E3835 Neighboring gene secretory carrier membrane protein 2 Neighboring gene complexin 3 Neighboring gene predicted gene, 32392 Neighboring gene lectin, mannose-binding 1 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway. Maloverjan A, et al. J Biol Chem, 2010 Sep 24. PMID 20643644, Free PMC Article
  2. The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway. Wang B, et al. Autophagy, 2018. PMID 29099309, Free PMC Article
  3. Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma. Mohammed Y, et al. NPJ Syst Biol Appl, 2021 May 28. PMID 34050187, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway.
    Title: Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fibroblast activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase ULK3
NP_082171.1
XP_036011189.1
XP_036011190.1
XP_036011191.1
XP_036011192.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027895.1 → NP_082171.1  serine/threonine-protein kinase ULK3

    See identical proteins and their annotated locations for NP_082171.1

    Status: VALIDATED

    Source sequence(s)
    AC122528, BC151153, CJ169382, CK023112
    Consensus CDS
    CCDS52809.1
    UniProtKB/Swiss-Prot
    B2RXB9, Q3U3Q1, Q8K1X6, Q9DBR8
    Related
    ENSMUSP00000059947.7, ENSMUST00000053230.7
    Conserved Domains (4) summary
    smart00220
    Location:14 → 270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02656
    Location:374 → 449
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cd02684
    Location:279 → 353
    MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
    cd14121
    Location:18 → 269
    STKc_ULK3; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    57496423..57503516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155296.1 → XP_036011189.1  serine/threonine-protein kinase ULK3 isoform X1

    Conserved Domains (3) summary
    cd02684
    Location:279 → 353
    MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
    cd14121
    Location:18 → 269
    STKc_ULK3; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3
    cl00299
    Location:374 → 425
    MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

  2. XM_036155298.1 → XP_036011191.1  serine/threonine-protein kinase ULK3 isoform X3

    Conserved Domains (3) summary
    cd02656
    Location:211 → 286
    MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl00299
    Location:116 → 190
    MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl21453
    Location:1 → 106
    PKc_like; Protein Kinases, catalytic domain

  3. XM_036155299.1 → XP_036011192.1  serine/threonine-protein kinase ULK3 isoform X3

    Conserved Domains (3) summary
    cd02656
    Location:211 → 286
    MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl00299
    Location:116 → 190
    MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl21453
    Location:1 → 106
    PKc_like; Protein Kinases, catalytic domain

  4. XM_036155297.1 → XP_036011190.1  serine/threonine-protein kinase ULK3 isoform X2

    Conserved Domains (3) summary
    cd02656
    Location:257 → 332
    MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cd02684
    Location:162 → 236
    MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
    cl21453
    Location:1 → 152
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_379456.5 RNA Sequence

  2. XR_004935557.1 RNA Sequence

  3. XR_379457.5 RNA Sequence

  4. XR_004935560.1 RNA Sequence

  5. XR_004935558.1 RNA Sequence

  6. XR_001779012.3 RNA Sequence

  7. XR_379458.1 RNA Sequence

  8. XR_870767.4 RNA Sequence

  9. XR_379459.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U3Q1.1 GenPept UniProtKB/Swiss-Prot:Q3U3Q1

Gene LinkOut

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