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Cul2 cullin 2 [ Mus musculus (house mouse) ]

Gene ID: 71745, updated on 23-Jun-2021

Summary

Official Symbol
Cul2provided by MGI
Official Full Name
cullin 2provided by MGI
Primary source
MGI:MGI:1918995
See related
Ensembl:ENSMUSG00000024231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI327301; mKIAA4106; 1300003D18Rik; 4932411N15Rik
Expression
Ubiquitous expression in placenta adult (RPKM 8.3), CNS E18 (RPKM 7.3) and 28 other tissues See more
Orthologs
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Genomic context

See Cul2 in Genome Data Viewer
Location:
18; 18 A1
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (3382970..3436700)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (3382970..3436700)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (3383223..3436698)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, 238 Neighboring gene cAMP responsive element modulator Neighboring gene predicted gene 6225 Neighboring gene profilin 1 pseudogene Neighboring gene BMP and activin membrane-bound inhibitor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4106

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of VCB complex ISO
Inferred from Sequence Orthology
more info
 
part_of cullin-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360829.1NP_001347758.1  cullin-2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124336
    Consensus CDS
    CCDS29032.2
    Related
    ENSMUSP00000025073.6, ENSMUST00000025073.12
    Conserved Domains (2) summary
    pfam00888
    Location:14644
    Cullin; Cullin family
    pfam10557
    Location:677735
    Cullin_Nedd8; Cullin protein neddylation domain
  2. NM_029402.3NP_083678.2  cullin-2

    See identical proteins and their annotated locations for NP_083678.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124336, AK004875, AK144693, AK162910
    Consensus CDS
    CCDS29032.2
    UniProtKB/Swiss-Prot
    Q9D4H8
    Related
    ENSMUSP00000125403.2, ENSMUST00000162301.8
    Conserved Domains (2) summary
    pfam00888
    Location:14644
    Cullin; Cullin family
    pfam10557
    Location:677735
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    3382970..3436700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526275.5XP_006526338.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_006526338.1

    UniProtKB/Swiss-Prot
    Q9D4H8
    Conserved Domains (2) summary
    pfam00888
    Location:14644
    Cullin; Cullin family
    pfam10557
    Location:677735
    Cullin_Nedd8; Cullin protein neddylation domain
  2. XM_030250610.2XP_030106470.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14644
    Cullin; Cullin family
    pfam10557
    Location:677735
    Cullin_Nedd8; Cullin protein neddylation domain
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