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Amdhd1 amidohydrolase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 71761, updated on 23-Jun-2021

Summary

Official Symbol
Amdhd1provided by MGI
Official Full Name
amidohydrolase domain containing 1provided by MGI
Primary source
MGI:MGI:1919011
See related
Ensembl:ENSMUSG00000015890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300019J08Rik
Expression
Biased expression in liver adult (RPKM 83.5) and liver E18 (RPKM 10.1) See more
Orthologs
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Genomic context

See Amdhd1 in Genome Data Viewer
Location:
10; 10 C2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93359200..93375973, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93523338..93540111, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (92986083..93002778, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene leukotriene A4 hydrolase Neighboring gene histidine ammonia lyase Neighboring gene coiled-coil domain containing 38 Neighboring gene RIKEN cDNA 4933408J17 gene Neighboring gene small nuclear ribonucleoprotein polypeptide F

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC148226

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA
Inferred from Electronic Annotation
more info
 
enables imidazolonepropionase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in histidine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histidine catabolic process to glutamate and formamide IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within histidine metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable imidazolonepropionase
Names
amidohydrolase domain-containing protein 1
NP_082184.1
XP_006514230.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027908.1NP_082184.1  probable imidazolonepropionase

    See identical proteins and their annotated locations for NP_082184.1

    Status: VALIDATED

    Source sequence(s)
    AK005066, AK090143, BB856590
    Consensus CDS
    CCDS48671.1
    UniProtKB/Swiss-Prot
    Q9DBA8
    Related
    ENSMUSP00000016034.3, ENSMUST00000016034.3
    Conserved Domains (2) summary
    COG1228
    Location:4426
    HutI; Imidazolonepropionase or related amidohydrolase [Secondary metabolites biosynthesis, transport and catabolism]
    cd01296
    Location:43420
    Imidazolone-5PH; Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    93359200..93375973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514167.4XP_006514230.1  probable imidazolonepropionase isoform X1

    Conserved Domains (1) summary
    cl00281
    Location:43345
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
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