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Klhdc3 kelch domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 71765, updated on 11-Apr-2024

Summary

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Official Symbol
Klhdc3provided by MGI
Official Full Name
kelch domain containing 3provided by MGI
Primary source
MGI:MGI:2651568
See related
Ensembl:ENSMUSG00000063576 AllianceGenome:MGI:2651568
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Peas; 1300011D16Rik
Summary
Predicted to enable chromatin binding activity and ubiquitin ligase-substrate adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to act upstream of or within meiotic cell cycle. Located in chromatin and cytoplasm. Orthologous to human KLHDC3 (kelch domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 250.5), cortex adult (RPKM 57.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 22.9 cM; 17 C
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46985476..46991856, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46674550..46680930, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cullin 7 Neighboring gene STARR-seq mESC enhancer starr_42676 Neighboring gene ribosomal RNA processing 36 Neighboring gene STARR-positive B cell enhancer mm9_chr17:46817738-46818039 Neighboring gene male enhanced antigen 1 Neighboring gene protein phosphatase 2, regulatory subunit B', delta Neighboring gene STARR-positive B cell enhancer ABC_E7538 Neighboring gene peroxisomal biogenesis factor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation. Zhang P, et al. Cell Death Differ, 2022 Apr. PMID 34743205, Free PMC Article
  2. Peas-Mea1-Ppp2r5d overlapping gene complex: a transposon mediated-gene formation in mammals. Ohinata Y, et al. DNA Res, 2003 Apr 30. PMID 12755172
  3. A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin. Ohinata Y, et al. FEBS Lett, 2003 Feb 27. PMID 12606021
  4. Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. Ohinata Y, et al. Biol Reprod, 2002 Dec. PMID 12444059
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
    Title: CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
  2. cloned human and mouse Peas cDNAs (hPEAS/mPeas) and analyzed their tissue and stage-specific expressions; may be involved in meiotic recombination process
    Title: A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch domain-containing protein 3
Names
protein Peas
testis intracellular mediator protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163729.2 → NP_001157201.2  kelch domain-containing protein 3

    See identical proteins and their annotated locations for NP_001157201.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK079082, AK141673, BY606590, CT030702
    Consensus CDS
    CCDS28834.1
    UniProtKB/Swiss-Prot
    Q3TCN9, Q3UR95, Q8VEM9, Q91XU6, Q99JH9, Q9DBG8
    UniProtKB/TrEMBL
    A0A0R4J0W0
    Related
    ENSMUSP00000128271.2, ENSMUST00000165007.9
    Conserved Domains (3) summary
    PLN02153
    Location:74 → 318
    PLN02153; epithiospecifier protein
    sd00038
    Location:128 → 173
    Kelch; KELCH repeat [structural motif]
    pfam13964
    Location:14 → 61
    Kelch_6; Kelch motif

  2. NM_027910.3 → NP_082186.2  kelch domain-containing protein 3

    See identical proteins and their annotated locations for NP_082186.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK004964, AK141673, BE945284, CF169399
    Consensus CDS
    CCDS28834.1
    UniProtKB/Swiss-Prot
    Q3TCN9, Q3UR95, Q8VEM9, Q91XU6, Q99JH9, Q9DBG8
    UniProtKB/TrEMBL
    A0A0R4J0W0
    Related
    ENSMUSP00000071743.6, ENSMUST00000071841.7
    Conserved Domains (3) summary
    PLN02153
    Location:74 → 318
    PLN02153; epithiospecifier protein
    sd00038
    Location:128 → 173
    Kelch; KELCH repeat [structural motif]
    pfam13964
    Location:14 → 61
    Kelch_6; Kelch motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46985476..46991856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524943.5 → XP_006525006.1  kelch domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006525006.1

    UniProtKB/Swiss-Prot
    Q3TCN9, Q3UR95, Q8VEM9, Q91XU6, Q99JH9, Q9DBG8
    UniProtKB/TrEMBL
    A0A0R4J0W0
    Conserved Domains (3) summary
    PLN02153
    Location:74 → 318
    PLN02153; epithiospecifier protein
    sd00038
    Location:128 → 173
    Kelch; KELCH repeat [structural motif]
    pfam13964
    Location:14 → 61
    Kelch_6; Kelch motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEM9.1 GenPept UniProtKB/Swiss-Prot:Q8VEM9

Gene LinkOut

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