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Klhdc3 kelch domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 71765, updated on 5-Jan-2022

Summary

Official Symbol
Klhdc3provided by MGI
Official Full Name
kelch domain containing 3provided by MGI
Primary source
MGI:MGI:2651568
See related
Ensembl:ENSMUSG00000063576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Peas; 1300011D16Rik
Summary
Predicted to enable chromatin binding activity and ubiquitin ligase-substrate adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to act upstream of or within meiotic cell cycle. Located in chromatin and cytoplasm. Orthologous to human KLHDC3 (kelch domain containing 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in testis adult (RPKM 250.5), cortex adult (RPKM 57.9) and 28 other tissues See more
Orthologs
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Genomic context

See Klhdc3 in Genome Data Viewer
Location:
17 22.9 cM; 17 C
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46985476..46991856, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46674550..46680930, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (46811499..46817879, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cullin 7 Neighboring gene ribosomal RNA processing 36 Neighboring gene male enhanced antigen 1 Neighboring gene protein phosphatase 2, regulatory subunit B', delta Neighboring gene peroxisomal biogenesis factor 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kelch domain-containing protein 3
Names
protein Peas
testis intracellular mediator protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163729.2NP_001157201.2  kelch domain-containing protein 3

    See identical proteins and their annotated locations for NP_001157201.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK079082, AK141673, BY606590, CT030702
    Consensus CDS
    CCDS28834.1
    UniProtKB/Swiss-Prot
    Q8VEM9
    UniProtKB/TrEMBL
    A0A0R4J0W0
    Related
    ENSMUSP00000128271.2, ENSMUST00000165007.9
    Conserved Domains (3) summary
    PLN02153
    Location:74318
    PLN02153; epithiospecifier protein
    sd00038
    Location:128173
    Kelch; KELCH repeat [structural motif]
    pfam13964
    Location:1461
    Kelch_6; Kelch motif
  2. NM_027910.3NP_082186.2  kelch domain-containing protein 3

    See identical proteins and their annotated locations for NP_082186.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK004964, AK141673, BE945284, CF169399
    Consensus CDS
    CCDS28834.1
    UniProtKB/Swiss-Prot
    Q8VEM9
    UniProtKB/TrEMBL
    A0A0R4J0W0
    Related
    ENSMUSP00000071743.6, ENSMUST00000071841.7
    Conserved Domains (3) summary
    PLN02153
    Location:74318
    PLN02153; epithiospecifier protein
    sd00038
    Location:128173
    Kelch; KELCH repeat [structural motif]
    pfam13964
    Location:1461
    Kelch_6; Kelch motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46985476..46991856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524943.5XP_006525006.1  kelch domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006525006.1

    UniProtKB/Swiss-Prot
    Q8VEM9
    UniProtKB/TrEMBL
    A0A0R4J0W0
    Conserved Domains (3) summary
    PLN02153
    Location:74318
    PLN02153; epithiospecifier protein
    sd00038
    Location:128173
    Kelch; KELCH repeat [structural motif]
    pfam13964
    Location:1461
    Kelch_6; Kelch motif
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