Raver1 ribonucleoprotein, PTB-binding 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Raver1provided by MGI
Official Full Name: ribonucleoprotein, PTB-binding 1provided by MGI
Primary source: MGI:MGI:1919016
See related: Ensembl:ENSMUSG00000010205 AllianceGenome:MGI:1919016
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1300006N24Rik
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; gut; liver; lung; and spleen. Orthologous to human RAVER1 (ribonucleoprotein, PTB binding 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 87.3), duodenum adult (RPKM 68.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.71 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (20985454..21003295, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (21074158..21091999, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

raver1 may play an important role for the regulation of neuronal synaptic plasticity, possibly by controlling especially the late LTP via posttranscriptional mechanisms.
Title: The hnRNP and cytoskeletal protein raver1 contributes to synaptic plasticity.
PTB-mediated splicing repression involves recruitment of raver1 as a potent splicing co-repressor.
Title: The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicing.
In mice, raver1 might link gene expression with structural functions of muscle contractility during muscle differentiation.
Title: Raver1 is an integral component of muscle contractile elements.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Readthrough Gm38431

Readthrough gene: Gm38431, Included gene: Fdx2

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ribonucleoprotein PTB-binding 1

Names: protein raver-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027911.4 → NP_082187.1 ribonucleoprotein PTB-binding 1

See identical proteins and their annotated locations for NP_082187.1

Status: VALIDATED

Source sequence(s)

AK138596, BC058271

Consensus CDS

CCDS40550.1

UniProtKB/Swiss-Prot

Q5DTT6, Q811K0, Q8C3Z1, Q8CA14, Q9CW46

UniProtKB/TrEMBL

A0A158RFV1

Related

ENSMUSP00000111150.2, ENSMUST00000115487.3

Conserved Domains (3) summary

cd12663
Location:59 → 129

RRM1_RAVER1; RNA recognition motif 1 in vertebrate ribonucleoprotein PTB-binding 1 (raver-1)

cd12667
Location:219 → 306

RRM3_RAVER1; RNA recognition motif 3 in vertebrate ribonucleoprotein PTB-binding 1 (raver-1)

cl17169
Location:133 → 209

RRM_SF; RNA recognition motif (RRM) superfamily