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Ap2b1 adaptor-related protein complex 2, beta 1 subunit [ Mus musculus (house mouse) ]

Gene ID: 71770, updated on 23-Jun-2021

Summary

Official Symbol
Ap2b1provided by MGI
Official Full Name
adaptor-related protein complex 2, beta 1 subunitprovided by MGI
Primary source
MGI:MGI:1919020
See related
Ensembl:ENSMUSG00000035152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AP105B; AI788979; 1300012O03Rik
Expression
Ubiquitous expression in testis adult (RPKM 73.6), CNS E18 (RPKM 36.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ap2b1 in Genome Data Viewer
Location:
11; 11 C
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83189545..83295861)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83298719..83405035)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (83116199..83218537)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene schlafen 14 Neighboring gene expressed sequence AA465934 Neighboring gene expressed sequence AI450353 Neighboring gene peroxisomal biogenesis factor 12 Neighboring gene small nucleolar RNA, C/D box 7 Neighboring gene predicted gene, 23951 Neighboring gene RAS-like, family 10, member B Neighboring gene growth arrest-specific 2 like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (2)  1 citation
  • Targeted (1) 
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in clathrin-dependent endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of AP-2 adaptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of AP-2 adaptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of clathrin adaptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of clathrin coat ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
AP-2 complex subunit beta
Names
adapter-related protein complex 2 beta subunit
adapter-related protein complex 2 subunit beta
adaptor protein complex AP-2 subunit beta
adaptor-related protein complex 2 subunit beta
beta-2-adaptin
beta-adaptin
beta2-adaptin
clathrin assembly protein complex 2 beta large chain
plasma membrane adaptor HA2/AP2 adaptin beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035854.2NP_001030931.1  AP-2 complex subunit beta isoform a

    See identical proteins and their annotated locations for NP_001030931.1

    Status: VALIDATED

    Source sequence(s)
    AK138434, AL603711
    Consensus CDS
    CCDS25161.1
    UniProtKB/Swiss-Prot
    Q9DBG3
    UniProtKB/TrEMBL
    Q5SWR1
    Related
    ENSMUSP00000018875.7, ENSMUST00000018875.13
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  2. NM_027915.3NP_082191.1  AP-2 complex subunit beta isoform b

    See identical proteins and their annotated locations for NP_082191.1

    Status: VALIDATED

    Source sequence(s)
    AK004975, AK138434, AL603711
    Consensus CDS
    CCDS25162.1
    UniProtKB/Swiss-Prot
    Q9DBG3
    UniProtKB/TrEMBL
    Q5SWR1
    Related
    ENSMUSP00000070714.8, ENSMUST00000065692.14
    Conserved Domains (4) summary
    smart00809
    Location:717817
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:826936
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    83189545..83295861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314772.3XP_017170261.1  AP-2 complex subunit beta isoform X1

    UniProtKB/Swiss-Prot
    Q9DBG3
    UniProtKB/TrEMBL
    Q5SWR1
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  2. XM_006534258.5XP_006534321.1  AP-2 complex subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006534321.1

    UniProtKB/Swiss-Prot
    Q9DBG3
    UniProtKB/TrEMBL
    Q5SWR1
    Related
    ENSMUSP00000135445.2, ENSMUST00000176523.2
    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
  3. XM_036156996.1XP_036012889.1  AP-2 complex subunit beta isoform X1

    Conserved Domains (4) summary
    smart00809
    Location:731831
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:840950
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:5175
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11534
    Adaptin_N; Adaptin N terminal region
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