Plbd2 phospholipase B domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plbd2provided by MGI
Official Full Name: phospholipase B domain containing 2provided by MGI
Primary source: MGI:MGI:1919022
See related: Ensembl:ENSMUSG00000029598 AllianceGenome:MGI:1919022
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P76; 1300012G16Rik
Summary: Predicted to enable phospholipase activity. Predicted to be involved in phospholipid catabolic process. Predicted to act upstream of or within lipid catabolic process. Located in lysosome. Orthologous to human PLBD2 (phospholipase B domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 51.3), testis adult (RPKM 42.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 60.63 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (120621958..120641688, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (120483893..120503623, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A 22-atom substructure of 21 intrinsic S atoms & 1 Xe atom with very low occupancy was found & refined at a resolution of 2.4A. The model was refined to an R(free) factor of 19.8%. The contribution of the Xe atom to the anomalous signal was negligible.
Title: De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: putative phospholipase B-like 2

Names: 66.3 kDa protein; 76 kDa protein; LAMA-like protein 2; lamina ancestor homolog 2; phospholipase B domain-containing protein 2

NP_076114.2

EC 3.1.1.-

XP_030110675.1

EC 3.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023625.4 → NP_076114.2 putative phospholipase B-like 2 precursor

See identical proteins and their annotated locations for NP_076114.2

Status: VALIDATED

Source sequence(s)

AK029813, AK042089, AK043608

Consensus CDS

CCDS19620.1

UniProtKB/Swiss-Prot

Q3TCN2, Q3TD43, Q3TPP8, Q8BHG8, Q8BMB6, Q8BXI3, Q8C0M4, Q8R0V3, Q9DBG4, Q9EQI9

Related

ENSMUSP00000031597.7, ENSMUST00000031597.7

Conserved Domains (1) summary

pfam04916
Location:86 → 589

Phospholip_B; Phospholipase B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

120621958..120641688 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254815.2 → XP_030110675.1 putative phospholipase B-like 2 isoform X1

Conserved Domains (1) summary

pfam04916
Location:1 → 315

Phospholip_B; Phospholipase B