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MAMU-DPB major histocompatibility complex, class II, DP beta [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 717969, updated on 5-Mar-2024

Summary

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Gene symbol
MAMU-DPB
Gene description
major histocompatibility complex, class II, DP beta
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
Mamu-DPB1
Orthologs
human all
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Genomic context

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Location:
chromosome: 4
Exon count:
6
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (136417890..136429207, complement)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (33920842..33932245)

Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene collagen type XI alpha 2 chain Neighboring gene uncharacterized LOC106997910 Neighboring gene uncharacterized LOC114677627 Neighboring gene uncharacterized LOC106997908 Neighboring gene major histocompatibility complex, class II, DP alpha Neighboring gene elongation factor 1-alpha 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Allelic diversity at the Mhc-DP locus in rhesus macaques (Macaca mulatta). Slierendregt BL, et al. Immunogenetics, 1995. PMID 7806271
  2. Characterization and distribution of Mhc-DPB1 alleles in chimpanzee and rhesus macaque populations. Otting N, et al. Hum Immunol, 1998 Oct. PMID 9757948
  3. The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers. Giraldo-Vela JP, et al. J Virol, 2008 Jan. PMID 17989178, Free PMC Article
  4. Molecular mechanism and cellular function of MHCII ubiquitination. Oh J, et al. Immunol Rev, 2015 Jul. PMID 26085212, Free PMC Article
  5. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MHC class II protein complex binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptide antigen assembly with MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
major histocompatibility complex, class II, DP beta
Names
MHC class II antigen
MHC class II protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361236.2 → NP_001348165.2  major histocompatibility complex, class II, DP beta precursor

    Status: VALIDATED

    Source sequence(s)
    QNVO02000341
    UniProtKB/TrEMBL
    A0A0M7BGI9, U6EFQ2
    Conserved Domains (2) summary
    pfam00969
    Location:42 → 112
    MHC_II_beta; Class II histocompatibility antigen, beta domain
    cd21003
    Location:121 → 216
    IgC1_MHC_II_beta_HLA-DP; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain of histocompatibility antigen (HLA) DP; member of the C1-set of Ig superfamily (IgSF) domains

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041757.1 Reference Mmul_10 Primary Assembly

    Range
    136417890..136429207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015136096.2 → XP_014991582.2  major histocompatibility complex, class II, DP beta

    Conserved Domains (2) summary
    pfam00969
    Location:42 → 112
    MHC_II_beta; Class II histocompatibility antigen, beta domain
    cd21003
    Location:121 → 216
    IgC1_MHC_II_beta_HLA-DP; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain of histocompatibility antigen (HLA) DP; member of the C1-set of Ig superfamily (IgSF) domains
Nucleotide Protein
Heading Accession and Version

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