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Kif23 kinesin family member 23 [ Mus musculus (house mouse) ]

Gene ID: 71819, updated on 21-Apr-2024

Summary

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Official Symbol
Kif23provided by MGI
Official Full Name
kinesin family member 23provided by MGI
Primary source
MGI:MGI:1919069
See related
Ensembl:ENSMUSG00000032254 AllianceGenome:MGI:1919069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHO1; Knsl5; MKLP1; MKLP-1; 3110001D19Rik
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including mitotic cytokinesis; mitotic spindle midzone assembly; and positive regulation of cytokinesis. Predicted to act upstream of or within cell division. Located in intercellular bridge. Is expressed in several structures, including alimentary system; hindbrain; nephrogenic zone; olfactory epithelium; and ventricular layer. Orthologous to human KIF23 (kinesin family member 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 14.9), liver E14 (RPKM 11.3) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 B; 9 33.5 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (61824559..61854078, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (61917277..61946810, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6748 Neighboring gene predicted gene, 35058 Neighboring gene ribosomal protein lateral stalk subunit P1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:61794519-61794820 Neighboring gene STARR-positive B cell enhancer mm9_chr9:61795876-61796177 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:61808677-61808878 Neighboring gene STARR-positive B cell enhancer ABC_E5075 Neighboring gene progestin and adipoQ receptor family member V Neighboring gene predicted gene, 35152 Neighboring gene glucuronyl C5-epimerase Neighboring gene microRNA 5133

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KIF23 Promotes Gastric Cancer by Stimulating Cell Proliferation. Li XL, et al. Dis Markers, 2019. PMID 31007778, Free PMC Article
  2. Differential tissue specific expression of Kif23 alternative transcripts in mice with the human mutation causing congenital dyserythropoietic anemia type III. Vikberg AL, et al. Blood Cells Mol Dis, 2020 Nov. PMID 32818800
  3. CHO1, a mammalian kinesin-like protein, interacts with F-actin and is involved in the terminal phase of cytokinesis. Kuriyama R, et al. J Cell Biol, 2002 Mar 4. PMID 11877456, Free PMC Article
  4. Phosphorylation of CHO1 by Lats1/2 regulates the centrosomal activation of LIMK1 during cytokinesis. Okamoto A, et al. Cell Cycle, 2015. PMID 25786116, Free PMC Article
  5. An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Iltzsche F, et al. Oncogene, 2017 Jan 5. PMID 27212033

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of KIF23 alleviates the progression of asthma by inhibiting pyroptosis.
    Title: Knockdown of KIF23 alleviates the progression of asthma by inhibiting pyroptosis.
  2. Differential tissue specific expression of Kif23 alternative transcripts in mice with the human mutation causing congenital dyserythropoietic anemia type III.
    Title: Differential tissue specific expression of Kif23 alternative transcripts in mice with the human mutation causing congenital dyserythropoietic anemia type III.
  3. Kif23 up-regulation promotes cell proliferation and gastric cancer progression.
    Title: KIF23 Promotes Gastric Cancer by Stimulating Cell Proliferation.
  4. depletion of KIF23 inhibited lung tumor formation in vivo, similar to what is seen with deletion of MMB. In vitro, the depletion of KIF23 in lung cancer cell lines showed strong anti-proliferative activity, which was accompanied by apoptosis in a subset of cell lines.
    Title: An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle midzone assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
  
part_of centralspindlin complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF23
Names
kinesin-like 5 (mitotic kinesin-like protein 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405055.1 → NP_001391984.1  kinesin-like protein KIF23 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC151969

  2. NM_001405056.1 → NP_001391985.1  kinesin-like protein KIF23 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC151969

  3. NM_001405057.1 → NP_001391986.1  kinesin-like protein KIF23 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC151969

  4. NM_024245.5 → NP_077207.3  kinesin-like protein KIF23 isoform 2

    See identical proteins and their annotated locations for NP_077207.3

    Status: VALIDATED

    Source sequence(s)
    AC151969
    Consensus CDS
    CCDS40662.1
    UniProtKB/Swiss-Prot
    E9Q5G3, Q80V30, Q99PT8
    Related
    ENSMUSP00000034815.8, ENSMUST00000034815.9
    Conserved Domains (4) summary
    cd01368
    Location:24 → 434
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:31 → 436
    Kinesin; Kinesin motor domain
    pfam08702
    Location:498 → 603
    Fib_alpha; Fibrinogen alpha/beta chain family
    pfam16540
    Location:797 → 896
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    61824559..61854078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244618.2 → XP_030100478.1  kinesin-like protein KIF23 isoform X4

    Conserved Domains (3) summary
    pfam05483
    Location:504 → 690
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    cd01368
    Location:24 → 448
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam16540
    Location:707 → 809
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

  2. XM_006511453.5 → XP_006511516.1  kinesin-like protein KIF23 isoform X2

    Conserved Domains (3) summary
    pfam05483
    Location:504 → 690
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    cd01368
    Location:24 → 448
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam16540
    Location:811 → 913
    MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q5G3.1 GenPept UniProtKB/Swiss-Prot:E9Q5G3

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