Dpep3 dipeptidase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpep3provided by MGI
Official Full Name: dipeptidase 3provided by MGI
Primary source: MGI:MGI:1919104
See related: Ensembl:ENSMUSG00000031898 AllianceGenome:MGI:1919104
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MBD-3; MLZ-136; 1700018F16Rik
Summary: Enables dipeptidase activity. Acts upstream of or within proteolysis. Located in acrosomal vesicle and plasma membrane. Is anchored component of membrane. Is expressed in gonad. Orthologous to human DPEP3 (dipeptidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 252.4) See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.07 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106700152..106706051, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (105973520..105979419, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data showed that Dpep3 mRNA was specifically detected in testis and DPEP3 is evolutionarily conserved among eutherians. Dpep3 knockout mice displayed normal fertility even a significant reduction in sperm count. These findings inferred that despite of the testis-specific expression pattern, Dpep3 is dispensable for mouse fertility.
Title: The testis-specifically expressed Dpep3 is not essential for male fertility in mice.
DPEP3 forms complexes with Ts4-immunoreactive molecules, such as TEX101, on the surfaces of spermatocytes, spermatids, and testicular spermatozoa.
Title: Molecular characterization and expression of dipeptidase 3, a testis-specific membrane-bound dipeptidase: complex formation with TEX101, a germ-cell-specific antigen in the mouse testis.
cloning and characterization of membrane-bound dipeptidase-2 and membrane-bound dipeptidase-3
Title: Identification of two additional members of the membrane-bound dipeptidase family.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables dipeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables dipeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallodipeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dipeptidase 3

Names: membrane-bound dipeptidase 3; protein expressed in male leptotene and zygotene spermatocytes 136; putative membrane-bound dipeptidase 3

NP_082236.1

EC 3.4.13.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.