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Cdca4 cell division cycle associated 4 [ Mus musculus (house mouse) ]

Gene ID: 71963, updated on 5-Mar-2024

Summary

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Official Symbol
Cdca4provided by MGI
Official Full Name
cell division cycle associated 4provided by MGI
Primary source
MGI:MGI:1919213
See related
Ensembl:ENSMUSG00000047832 AllianceGenome:MGI:1919213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HEPP; SEI-3; 2410018C03Rik
Summary
Predicted to be involved in epigenetic maintenance of chromatin in transcription-competent conformation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; neural ectoderm; and sensory organ. Orthologous to human CDCA4 (cell division cycle associated 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 31.9), CNS E11.5 (RPKM 24.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Cdca4 in Genome Data Viewer
Location:
12 F1; 12 61.2 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112783849..112793141, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112820229..112829521, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene AHNAK nucleoprotein 2 Neighboring gene clathrin binding box of aftiphilin containing 1 Neighboring gene STARR-seq mESC enhancer starr_33365 Neighboring gene STARR-seq mESC enhancer starr_33367 Neighboring gene predicted gene, 52009 Neighboring gene STARR-seq mESC enhancer starr_33369 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114093201-114093409 Neighboring gene G protein-coupled receptor 132 Neighboring gene predicted gene, 30461 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114108177-114108360 Neighboring gene RIKEN cDNA 1700127F24 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP). Bennetts JS, et al. Gene, 2006 Jun 7. PMID 16546331
  2. Cloning and characterization of Hepp, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells. Abdullah JM, et al. Blood Cells Mol Dis, 2001 May-Jun. PMID 11482882
  3. Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts. Peng Y, et al. Biochem Biophys Res Commun, 2013 Nov 29. PMID 24211589, Free PMC Article
  4. SEI family of nuclear factors regulates p53-dependent transcriptional activation. Watanabe-Fukunaga R, et al. Genes Cells, 2005 Aug. PMID 16098148
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ALKBH5 promotes the development of lung adenocarcinoma by regulating the polarization of M2 macrophages through CDCA4.
    Title: ALKBH5 promotes the development of lung adenocarcinoma by regulating the polarization of M2 macrophages through CDCA4.
  2. The evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein Cdca4 was studied.
    Title: Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Clone Names

  • 2410018C03Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell division cycle-associated protein 4
Names
hematopoietic progenitor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359234.1 → NP_001346163.1  cell division cycle-associated protein 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the shortest transcript. All variants encode the same protein.
    Source sequence(s)
    AF322238, AK010535, BY199153
    Consensus CDS
    CCDS26198.1
    UniProtKB/Swiss-Prot
    Q3U1C0, Q921E8, Q99MP6, Q9CWM2
    UniProtKB/TrEMBL
    Q3USY8
    Related
    ENSMUSP00000152315.2, ENSMUST00000220899.2
    Conserved Domains (1) summary
    pfam06031
    Location:33 → 68
    SERTA; SERTA motif

  2. NM_001359292.1 → NP_001346221.1  cell division cycle-associated protein 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. All variants encode the same protein.
    Source sequence(s)
    AC160929, AF322238, BY201887
    Consensus CDS
    CCDS26198.1
    UniProtKB/Swiss-Prot
    Q3U1C0, Q921E8, Q99MP6, Q9CWM2
    UniProtKB/TrEMBL
    Q3USY8
    Conserved Domains (1) summary
    pfam06031
    Location:33 → 68
    SERTA; SERTA motif

  3. NM_028023.4 → NP_082299.1  cell division cycle-associated protein 4

    See identical proteins and their annotated locations for NP_082299.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. All variants encode the same protein.
    Source sequence(s)
    AC160929, AF322238
    Consensus CDS
    CCDS26198.1
    UniProtKB/Swiss-Prot
    Q3U1C0, Q921E8, Q99MP6, Q9CWM2
    UniProtKB/TrEMBL
    Q3USY8
    Related
    ENSMUSP00000058901.6, ENSMUST00000062092.7
    Conserved Domains (1) summary
    pfam06031
    Location:33 → 68
    SERTA; SERTA motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    112783849..112793141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWM2.2 GenPept UniProtKB/Swiss-Prot:Q9CWM2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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